{"id":"ba244853-bcc7-5429-b94c-41b953c439c5","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ileal-iron","predicate":"reduces","statement":"Apparent iron absorption fell in this ileostomy experiment.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9000d688-41f3-51c2-b943-7616909bbf27","mechanism_event_label":"Less iron disappeared before the end of the small intestine.","subject":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9000d688-41f3-51c2-b943-7616909bbf27","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ileal-iron-event","event_type":"observed_intervention","label":"Less iron disappeared before the end of the small intestine.","description":"Apparent iron absorption fell in this ileostomy experiment.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"measured_substance","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/6307932.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\", \"start_char\": 0, \"end_char\": 1593, \"text_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Within-person ileostomy balance study; six participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Less iron disappeared before the end of the small intestine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. (1983). https://pubmed.ncbi.nlm.nih.gov/6307932/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small intestine; ileal effluent","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3b062117-af73-5c42-ad02-4e6334d175f8","evidence_kind":"source_excerpt","locator":"Lines 542-553","start_line":542,"end_line":553,"excerpt":"### pectin-ileal-iron\nApparent iron absorption fell in this ileostomy experiment.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Less iron disappeared before the end of the small intestine.\norganism: Homo sapiens\ntissue_or_cell_type: Small intestine; ileal effluent\nexperimental_model: Within-person ileostomy balance study; six participants\nlimitations: Ileal apparent absorption and output are not whole-body status or clinical deficiency; the colon was bypassed.\nexposure: 15 g/day citrus pectin on days 5-7 of a 10-day low-fiber feeding protocol\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/6307932.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\", \"start_char\": 0, \"end_char\": 1593, \"text_sha256\": \"fd45607a7ff1d1a20dd52d145134da591847919c3db47ef8a8cf5693fb9f80a1\"}\n[pectin-p6307932] The effect of citrus pectin on the absorption of nutrients in the small intestine. 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