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topical membership is not evidence of a direct dietary effect.\nplain_language: The installed arm enables oxidation of folate-bound carbon.\norganism: Homo sapiens\ntissue_or_cell_type: Cell-free\nexperimental_model: Recombinant enzyme activation assay\nlimitations: Figure 5 used stable dideazafolate analogue rather than physiological folate.\nexposure: Assay conditions described in the linked primary study.\ncross_nutrient: CoA maturation enables the folate-to-NADPH reaction.\n[strickland-2011] Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase (2011). https://pubmed.ncbi.nlm.nih.gov/21238436/ DOI: 10.1016/j.cbi.2011.01.008","model_system":"Recombinant enzyme activation assay","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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