{"id":"ba214927-6a36-5188-b120-548085857119","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-calmodulin-calcineurin-activation","predicate":"activates","statement":"Calcium/calmodulin binding folds the human calcineurin regulatory region and supports displacement of autoinhibition.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8a8d889e-c566-5738-9cc1-fa6d7dedff19","mechanism_event_label":"Calcium-bound calmodulin helps switch on calcineurin.","subject":{"id":"a79ecb55-2003-5544-9599-c2136624394a","slug":"calcium-calmodulin","display_name":"Calcium/calmodulin","entity_type_key":"protein_complex"},"object":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"8a8d889e-c566-5738-9cc1-fa6d7dedff19","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:ca-calmodulin-calcineurin-activation-event","event_type":"regulation","label":"Calcium-bound calmodulin helps switch on calcineurin.","description":"Calcium/calmodulin binding folds the human calcineurin regulatory region and supports displacement of autoinhibition.","status":"provisional","compartment":{"slug":"cytosol","display_name":"Cytosol"},"participants":[{"entity":{"id":"a79ecb55-2003-5544-9599-c2136624394a","slug":"calcium-calmodulin","display_name":"Calcium/calmodulin","entity_type_key":"protein_complex"},"role":"activator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"27eef74a-1d9b-57b3-a245-82d452d6cb54","slug":"calcineurin","display_name":"Calcineurin","entity_type_key":"protein_complex"},"role":"regulated_phosphatase","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"regulatory_ligand","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bc9ed3a1-38d5-5bc3-b2a5-9f9f7633660b","slug":"cytosol","display_name":"Cytosol","entity_type_key":"organelle"},"role":"experimental_location","stoichiometry":null,"state_label":"","sequence_order":3,"notes":"Study location; presence here is not a separate transport or causal claim."}]},"contexts":[{"dimension":"compartment_description","value_text":"Cytosol","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human alpha-calcineurin, regulatory fragments and calmodulin; spectroscopy and exchange mass spectrometry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Fragment and biochemical data support a regulatory mechanism; not tissue-level output.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium-bound calmodulin helps switch on calcineurin.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ca-rumimasante2012] Structural basis for activation of calcineurin by calmodulin (2012). https://pubmed.ncbi.nlm.nih.gov/22100452/ DOI: 10.1016/j.jmb.2011.11.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"research_relationship_category","value_text":"regulation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Recombinant signaling proteins","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"49958d81-891d-508f-9b36-2cd0ff079259","evidence_kind":"source_excerpt","locator":"Lines 412-423","start_line":412,"end_line":423,"excerpt":"### ca-calmodulin-calcineurin-activation\nCalcium/calmodulin binding folds the human calcineurin regulatory region and supports displacement of autoinhibition.\nCondition category: normal\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium-bound calmodulin helps switch on calcineurin.\norganism: Homo sapiens\ntissue_or_cell_type: Recombinant signaling proteins\nexperimental_model: Recombinant human alpha-calcineurin, regulatory fragments and calmodulin; spectroscopy and exchange mass spectrometry\nlimitations: Fragment and biochemical data support a regulatory mechanism; not tissue-level output.\nresearch_relationship_category: regulation\ncompartment_description: Cytosol\n[ca-rumimasante2012] Structural basis for activation of calcineurin by calmodulin (2012). https://pubmed.ncbi.nlm.nih.gov/22100452/ DOI: 10.1016/j.jmb.2011.11.008","model_system":"Recombinant human alpha-calcineurin, regulatory fragments and calmodulin; spectroscopy and exchange mass spectrometry","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ca-rumimasante2012] Structural basis for activation of calcineurin by calmodulin (2012). https://pubmed.ncbi.nlm.nih.gov/22100452/ DOI: 10.1016/j.jmb.2011.11.008","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}