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topical membership is not evidence of a direct dietary effect.\nplain_language: The human assembly factor physically associated with the flavin-bearing subunit.\norganism: Homo sapiens\ntissue_or_cell_type: HEK293 cells\nexperimental_model: Yeast genetics, recombinant coexpression, human HEK293 binding assays and familial paraganglioma tissue.\nlimitations: Coimmunoprecipitation does not by itself establish the chemistry of FAD attachment.\nexposure: No nutrient intervention; structural or biochemical characterization.\nevidence_spans: [{\"source_bundle\": \"artifacts/riboflavin_metabolism_sources.json\", \"source_key\": \"PMC3881419\", \"locator\": \"HTML article p\", \"paragraph_index\": 21, \"char_start\": 0, \"char_end\": 672, \"evidence_access\": \"full-text\"}]\n[hao-2009-sdh5] SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma (2009). https://pubmed.ncbi.nlm.nih.gov/19628817/ DOI: 10.1126/science.1175689","model_system":"Yeast genetics, recombinant coexpression, human HEK293 binding assays and familial paraganglioma tissue.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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