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The same year’s consensus was later challenged by AMPK-independent findings recorded in this collection.\nexposure: Metformin in LKB1-deficient livers\nevidence_span: {\"source_cache\": \"artifacts/metformin-research/16308421.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e4762199db357f0f8002a9da8ff2ecad8e9bfcb48c963eb4b2cde7ffa363eec4\", \"start_char\": 0, \"end_char\": 1103, \"text_sha256\": \"e4762199db357f0f8002a9da8ff2ecad8e9bfcb48c963eb4b2cde7ffa363eec4\"}\n[metformin-p16308421] The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. (2005). https://pubmed.ncbi.nlm.nih.gov/16308421/ DOI: 10.1126/science.1120781","model_system":"Liver-specific LKB1 deletion in adult mice with adenoviral TORC2 knockdown","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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