{"id":"b9adde4b-c5dd-5c36-814a-1bb11d73b8a9","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-absorption","predicate":"appears_in","statement":"After oral carnosine, healthy volunteers excreted intact peptide over five hours, with recovery reaching 14% of the dose in some participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"92a818b3-a7ec-5f5a-b546-e2af8ec0bb5a","mechanism_event_label":"Some intact carnosine crosses the intestine.","subject":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"object":{"id":"02e93a91-93d1-590d-a52a-60314ca54d25","slug":"human-urinary-intact-carnosine","display_name":"Human urinary intact carnosine recovery","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"92a818b3-a7ec-5f5a-b546-e2af8ec0bb5a","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-absorption-event","event_type":"observed_relationship","label":"Some intact carnosine crosses the intestine.","description":"After oral carnosine, healthy volunteers excreted intact peptide over five hours, with recovery reaching 14% of the dose in some participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"02e93a91-93d1-590d-a52a-60314ca54d25","slug":"human-urinary-intact-carnosine","display_name":"Human urinary intact carnosine recovery","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human oral administration and urine sampling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Urine recovery is not the fraction retained in tissues.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Carnosine collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Some intact carnosine crosses the intestine.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1910085/ · DOI 10.1113/jphysiol.1991.sp018673","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"205c9ebc-1967-5332-a19b-10c17b8a6643","evidence_kind":"source_excerpt","locator":"Lines 76-82","start_line":76,"end_line":82,"excerpt":"## carnosine-absorption\nSome intact carnosine crosses the intestine.\nAfter oral carnosine, healthy volunteers excreted intact peptide over five hours, with recovery reaching 14% of the dose in some participants.\nModel: Human oral administration and urine sampling.\nLimitations: Urine recovery is not the fraction retained in tissues.\nEvidence access: Primary abstract\nIntestinal absorption of the intact peptide carnosine in man, and comparison with intestinal permeability to lactulose. · 1991 · https://pubmed.ncbi.nlm.nih.gov/1910085/ · DOI 10.1113/jphysiol.1991.sp018673","model_system":"Human oral administration and urine sampling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"87dc5af2-4eb6-5980-b7e0-bf3697b1156e","stable_key":"import-ae1ed35d-8ce7-5936-9067-a641374bbf79","title":"Carnosine: synthesis, transport, carbonyl chemistry and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"469cbc38203db56bd031f9d8a2dd2bfa387713950ca30199511cd137e927aa7a","revision_id":"cc409a15-8b04-50ee-a7ff-d1bf32f686bb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}