{"id":"b9a52b94-f497-5d41-a95d-13ad7b5e9704","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-gi","predicate":"causes_reported","statement":"The 150- and 300-mg/day sulfate regimens caused some gastrointestinal intolerance during the six-week trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f21a89d6-3526-50f8-98fc-4dd5ecf30869","mechanism_event_label":"Tolerability limits matter alongside the metabolic signals.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"ff2fddd0-3759-5dbe-911c-800b2b912dbb","slug":"human-vanadyl-gastrointestinal-intolerance","display_name":"Gastrointestinal intolerance during vanadyl sulfate studies","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f21a89d6-3526-50f8-98fc-4dd5ecf30869","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-gi-event","event_type":"observed_relationship","label":"Tolerability limits matter alongside the metabolic signals.","description":"The 150- and 300-mg/day sulfate regimens caused some gastrointestinal intolerance during the six-week trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ff2fddd0-3759-5dbe-911c-800b2b912dbb","slug":"human-vanadyl-gastrointestinal-intolerance","display_name":"Gastrointestinal intolerance during vanadyl sulfate studies","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small human type-2-diabetes study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Short follow-up and limited endpoints do not establish long-term safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Tolerability limits matter alongside the metabolic signals.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fce91ff5-9169-5f5f-805c-fb264be03d7b","evidence_kind":"source_excerpt","locator":"Lines 406-412","start_line":406,"end_line":412,"excerpt":"## vanadium-human-gi\nTolerability limits matter alongside the metabolic signals.\nThe 150- and 300-mg/day sulfate regimens caused some gastrointestinal intolerance during the six-week trial.\nModel: Small human type-2-diabetes study.\nLimitations: Short follow-up and limited endpoints do not establish long-term safety.\nEvidence access: Primary abstract\nMetabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","model_system":"Small human type-2-diabetes study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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