{"id":"b96f4f1a-cda9-5719-9d91-d2c55c7d41a2","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-gemfibrozil-acid","predicate":"increases_tested","statement":"Gemfibrozil 600 mg twice daily increased lovastatin-acid peak concentration and exposure area after LipoCol Forte in 13 volunteers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"30911b8d-b81a-5b65-b3f2-67bfff1a89d9","mechanism_event_label":"A coadministered drug increased exposure to the active acid.","subject":{"id":"be172818-3b91-5a27-8657-a620397442da","slug":"gemfibrozil","display_name":"Gemfibrozil","entity_type_key":"drug"},"object":{"id":"5dcb50cd-6f97-5bb5-806c-277c8a5fed88","slug":"human-lovastatin-acid-plasma-exposure","display_name":"Human plasma exposure to lovastatin hydroxy acid","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"30911b8d-b81a-5b65-b3f2-67bfff1a89d9","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-gemfibrozil-acid-event","event_type":"observed_relationship","label":"A coadministered drug increased exposure to the active acid.","description":"Gemfibrozil 600 mg twice daily increased lovastatin-acid peak concentration and exposure area after LipoCol Forte in 13 volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"be172818-3b91-5a27-8657-a620397442da","slug":"gemfibrozil","display_name":"Gemfibrozil","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5dcb50cd-6f97-5bb5-806c-277c8a5fed88","slug":"human-lovastatin-acid-plasma-exposure","display_name":"Human plasma exposure to lovastatin hydroxy acid","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"30978ef1-162a-52bd-bb88-2e506565f5bc","slug":"lipocol-forte-2012","display_name":"LipoCol Forte red yeast rice preparation studied in 2012","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bd3bb602-9a12-5d58-8130-538236270e6f","slug":"lovastatin-acid","display_name":"Lovastatin hydroxy acid / monacolin KA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary full text PMC3513969","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human short-course gemfibrozil followed by one LipoCol Forte capsule.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The trial did not establish a unique responsible transporter or enzyme, nor measure a muscle-injury incidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"red-yeast-rice","display_name":"Red yeast rice","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A coadministered drug increased exposure to the active acid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[23227093] Interaction between Red Yeast Rice and CYP450 Enzymes/P-Glycoprotein and Its Implication for the Clinical Pharmacokinetics of Lovastatin. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23227093/ · DOI 10.1155/2012/127043","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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