{"id":"b9404f75-4c44-5a3d-a2fb-a6eb73487f69","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-mouse-lifespan","predicate":"increases","statement":"Starting 1000 mg/kg/day taurine at 14 months increased median lifespan by approximately 10–12% in the reported male and female mouse cohorts.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"53bded32-6470-5dff-861a-0d175457f309","mechanism_event_label":"The mouse intervention reported longer survival.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"33923b33-cc4a-57a9-bdfd-6fad0023146b","slug":"mouse-taurine-lifespan","display_name":"Mouse lifespan in the 2023 taurine supplementation study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"53bded32-6470-5dff-861a-0d175457f309","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-aging-mouse-lifespan-event","event_type":"observed_relationship","label":"The mouse intervention reported longer survival.","description":"Starting 1000 mg/kg/day taurine at 14 months increased median lifespan by approximately 10–12% in the reported male and female mouse cohorts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"33923b33-cc4a-57a9-bdfd-6fad0023146b","slug":"mouse-taurine-lifespan","display_name":"Mouse lifespan in the 2023 taurine supplementation study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text, lifespan results and Figure 1","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"C57BL/6J mice treated daily until death; same chow in both arms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High animal exposure is not a human dose or proof of human lifespan extension.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The mouse intervention reported longer survival.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Taurine deficiency as a driver of aging. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37289866/ · DOI 10.1126/science.abn9257","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2a35a4be-cbc6-5132-9926-4b93c1e5fa3d","evidence_kind":"source_excerpt","locator":"Lines 593-599","start_line":593,"end_line":599,"excerpt":"## taurine-aging-mouse-lifespan\nThe mouse intervention reported longer survival.\nStarting 1000 mg/kg/day taurine at 14 months increased median lifespan by approximately 10–12% in the reported male and female mouse cohorts.\nModel: C57BL/6J mice treated daily until death; same chow in both arms.\nLimitations: High animal exposure is not a human dose or proof of human lifespan extension.\nEvidence access: Primary full text, lifespan results and Figure 1\nTaurine deficiency as a driver of aging. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37289866/ · DOI 10.1126/science.abn9257","model_system":"C57BL/6J mice treated daily until death; same chow in both arms.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}