{"id":"b90d3754-0050-5df0-bdee-6053c040f16f","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-cold-duration-positive","predicate":"shortened","statement":"Mean overall cold duration was 4.0 days with zinc versus 7.1 with placebo (P<.0001); cough lasted 2.1 versus 5.0 days and nasal discharge 3.0 versus 4.5 days.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"0516bbc8-0c68-5e77-b7f8-66cea763018d","mechanism_event_label":"This small acetate-lozenge trial found shorter symptoms.","subject":{"id":"e3ffa4c2-7a90-54df-9c08-1a296e4f6c02","slug":"zinc-acetate","display_name":"Zinc acetate","entity_type_key":"chemical_species"},"object":{"id":"5393537d-7989-5510-bee5-609cef784929","slug":"common-cold-duration","display_name":"Common cold symptom duration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"0516bbc8-0c68-5e77-b7f8-66cea763018d","stable_key":"6d38d43e-01e4-5641-93be-65654271e242:zn-clin-cold-duration-positive-event","event_type":"observed_intervention","label":"This small acetate-lozenge trial found shorter symptoms.","description":"Mean overall cold duration was 4.0 days with zinc versus 7.1 with placebo (P<.0001); cough lasted 2.1 versus 5.0 days and nasal discharge 3.0 versus 4.5 days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e3ffa4c2-7a90-54df-9c08-1a296e4f6c02","slug":"zinc-acetate","display_name":"Zinc acetate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5393537d-7989-5510-bee5-609cef784929","slug":"common-cold-duration","display_name":"Common cold symptom duration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Zinc exposure and the specifically measured response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Indexed primary abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/zinc-clinical-sources/prasad2008.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"fbee9b28c3866295933e0baab1770cdaab0b62567ec2787a587522e493051b6e\", \"utf8_bytes\": 1456}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized placebo-controlled trial in 50 adults enrolled within 24 hours of cold onset","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"One lozenge with 13.3 mg elemental zinc as acetate every 2–3 hours while awake.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small trial with subjective symptoms; biomarker differences do not prove the proposed antioxidant or anti-inflammatory pathway mediates benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Zinc research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"zinc","display_name":"Zinc","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This small acetate-lozenge trial found shorter symptoms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[zn-clin-prasad2008] Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. (2008). https://pubmed.ncbi.nlm.nih.gov/18279051/ DOI: 10.1086/528803","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Upper respiratory symptoms","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"323ab317-c4d3-5ca7-94cf-ab07b6836240","evidence_kind":"source_excerpt","locator":"Lines 1543-1556","start_line":1543,"end_line":1556,"excerpt":"### zn-clin-cold-duration-positive\nMean overall cold duration was 4.0 days with zinc versus 7.1 with placebo (P<.0001); cough lasted 2.1 versus 5.0 days and nasal discharge 3.0 versus 4.5 days.\nCondition category: normal\nnutrient_topic: Zinc research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This small acetate-lozenge trial found shorter symptoms.\norganism: Homo sapiens\ntissue_or_cell_type: Upper respiratory symptoms\nexperimental_model: Double-blind randomized placebo-controlled trial in 50 adults enrolled within 24 hours of cold onset\nlimitations: Small trial with subjective symptoms; biomarker differences do not prove the proposed antioxidant or anti-inflammatory pathway mediates benefit.\nexposure: One lozenge with 13.3 mg elemental zinc as acetate every 2–3 hours while awake.\ncross_nutrient: Zinc exposure and the specifically measured response.\nevidence_location: Indexed primary abstract.\nevidence_span: {\"source_cache\": \"artifacts/zinc-clinical-sources/prasad2008.abstract.txt\", \"locator\": \"Primary indexed abstract; complete local file\", \"file_sha256\": \"fbee9b28c3866295933e0baab1770cdaab0b62567ec2787a587522e493051b6e\", \"utf8_bytes\": 1456}\n[zn-clin-prasad2008] Duration and severity of symptoms and levels of plasma interleukin-1 receptor antagonist, soluble tumor necrosis factor receptor, and adhesion molecules in patients with common cold treated with zinc acetate. 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