{"id":"b8f4517d-4816-5431-9405-432791d45e2c","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-selenium-combination-mortality","predicate":"with_selenium_reduced_trial_incidence_of","statement":"Cardiovascular mortality was 5.9% with combined selenium/CoQ versus 12.6% with placebo in the Swedish trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"225bf048-59c4-5153-bff3-a74560c065c8","mechanism_event_label":"The combination had a favorable result, but the design cannot tell how much came from each component.","subject":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"object":{"id":"85e44dc1-3709-5913-b735-3e3c9f9bf9e8","slug":"cardiovascular-mortality","display_name":"Cardiovascular mortality","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"225bf048-59c4-5153-bff3-a74560c065c8","stable_key":"3b5aff9b-4086-5574-bfb4-3ea49ba520d7:coq10-selenium-combination-mortality-event","event_type":"observed_intervention","label":"The combination had a favorable result, but the design cannot tell how much came from each component.","description":"Cardiovascular mortality was 5.9% with combined selenium/CoQ versus 12.6% with placebo in the Swedish trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"cointervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1bcf0ac-3578-5afa-97d7-ef3551b657c5","slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"85e44dc1-3709-5913-b735-3e3c9f9bf9e8","slug":"cardiovascular-mortality","display_name":"Cardiovascular mortality","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/coq10-research/22626835.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\", \"start_char\": 0, \"end_char\": 1797, \"text_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind combined-supplement trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Selenium plus CoQ10 versus placebo; 5.2-year follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Combined intervention without selenium-only and CoQ-only arms; no independent CoQ effect or statistical nutrient synergy can be identified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"coq10","display_name":"Coenzyme Q10 / CoQ10 redox system","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"443 Swedish adults aged 70-88","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The combination had a favorable result, but the design cannot tell how much came from each component.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. (2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Cardiovascular mortality and cardiac measurements","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a124b62e-7d5e-5d74-9d25-8dd1f4c26593","evidence_kind":"source_excerpt","locator":"Lines 1126-1137","start_line":1126,"end_line":1137,"excerpt":"### coq10-selenium-combination-mortality\nCardiovascular mortality was 5.9% with combined selenium/CoQ versus 12.6% with placebo in the Swedish trial.\nCondition category: normal\nnutrient_topic: Coenzyme Q10 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combination had a favorable result, but the design cannot tell how much came from each component.\norganism: 443 Swedish adults aged 70-88\ntissue_or_cell_type: Cardiovascular mortality and cardiac measurements\nexperimental_model: Randomized double-blind combined-supplement trial\nlimitations: Combined intervention without selenium-only and CoQ-only arms; no independent CoQ effect or statistical nutrient synergy can be identified.\nexposure: Selenium plus CoQ10 versus placebo; 5.2-year follow-up\nevidence_span: {\"source_cache\": \"artifacts/coq10-research/22626835.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\", \"start_char\": 0, \"end_char\": 1797, \"text_sha256\": \"68f71b162945240d48d14b42d132856ad242c2cc57640eae3a60a3aaa2706587\"}\n[coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. (2013). https://pubmed.ncbi.nlm.nih.gov/22626835/ DOI: 10.1016/j.ijcard.2012.04.156","model_system":"Randomized double-blind combined-supplement trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [coq10-p22626835] Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens. 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