{"id":"b8e35198-9bd3-5320-89e6-bfcbd6bd2f84","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:potassium-citrate-reduces-calcium-stone-formation","predicate":"decreases","statement":"Potassium citrate reduced new stone formation relative to placebo among participants followed for three years in the hypocitraturic calcium-stone trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"cf0f3803-b275-5ef2-8ca7-83595fd7244b","mechanism_event_label":"The combined salt changed a stone outcome in a selected clinical group.","subject":{"id":"3b29ab32-ccaf-5805-9eb4-894dd7c30a6b","slug":"potassium-citrate","display_name":"Potassium citrate","entity_type_key":"chemical_species"},"object":{"id":"f1fb5d71-ca83-5ff7-afc0-e3602cb047d0","slug":"calcium-stone-formation","display_name":"Calcium stone formation rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"cf0f3803-b275-5ef2-8ca7-83595fd7244b","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:potassium-citrate-reduces-calcium-stone-formation-event","event_type":"observed_intervention","label":"The combined salt changed a stone outcome in a selected clinical group.","description":"Potassium citrate reduced new stone formation relative to placebo among participants followed for three years in the hypocitraturic calcium-stone trial.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3b29ab32-ccaf-5805-9eb4-894dd7c30a6b","slug":"potassium-citrate","display_name":"Potassium citrate","entity_type_key":"chemical_species"},"role":"upstream","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f1fb5d71-ca83-5ff7-afc0-e3602cb047d0","slug":"calcium-stone-formation","display_name":"Calcium stone formation rate","entity_type_key":"cellular_process"},"role":"downstream","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1c54abac-4dfd-5303-b0f4-37945245e18e","slug":"citrate","display_name":"Citrate","entity_type_key":"small_molecule"},"role":"co-delivered-anion","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5dd31e52-f51e-51f3-880e-240abcc0ab1d","slug":"potassium-ion","display_name":"Potassium ion","entity_type_key":"ion"},"role":"co-delivered-ion","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"stone-component","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Citrate/alkali coadministration with potassium modifies calcium-stone formation in hypocitraturic stone formers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"endpoint","value_text":"Potassium citrate reduced new stone formation relative to placebo among participants followed for three years in the hypocitraturic calcium-stone trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental-exposure","value_text":"Fifty-seven people with recurrent calcium stones and hypocitraturia randomized to potassium citrate 30-60 mEq/day or placebo; three-year outcomes in 18 and 20 respectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fifty-seven people with recurrent calcium stones and hypocitraturia randomized to potassium citrate 30-60 mEq/day or placebo; three-year outcomes in 18 and 20 respectively.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"57 randomized but 38 contributed the cited three-year comparison; potassium, citrate and alkalinization were cointerventions. Not a potassium-cation-only effect or treatment recommendation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The combined salt changed a stone outcome in a selected clinical group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[barcelo-1993-stones] Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis (1993). https://www.sciencedirect.com/science/article/pii/S0022534717358883 DOI: 10.1016/S0022-5347(17)35888-3","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"urinary tract","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"947b48dc-b779-5eaf-aac1-53793986b5d4","evidence_kind":"source_excerpt","locator":"Lines 1438-1450","start_line":1438,"end_line":1450,"excerpt":"### potassium-citrate-reduces-calcium-stone-formation\nPotassium citrate reduced new stone formation relative to placebo among participants followed for three years in the hypocitraturic calcium-stone trial.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The combined salt changed a stone outcome in a selected clinical group.\norganism: Homo sapiens\ntissue_or_cell_type: urinary tract\nexperimental_model: Fifty-seven people with recurrent calcium stones and hypocitraturia randomized to potassium citrate 30-60 mEq/day or placebo; three-year outcomes in 18 and 20 respectively.\nlimitations: 57 randomized but 38 contributed the cited three-year comparison; potassium, citrate and alkalinization were cointerventions. Not a potassium-cation-only effect or treatment recommendation.\ncross_nutrient: Citrate/alkali coadministration with potassium modifies calcium-stone formation in hypocitraturic stone formers.\nexperimental-exposure: Fifty-seven people with recurrent calcium stones and hypocitraturia randomized to potassium citrate 30-60 mEq/day or placebo; three-year outcomes in 18 and 20 respectively.\nendpoint: Potassium citrate reduced new stone formation relative to placebo among participants followed for three years in the hypocitraturic calcium-stone trial.\n[barcelo-1993-stones] Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis (1993). https://www.sciencedirect.com/science/article/pii/S0022534717358883 DOI: 10.1016/S0022-5347(17)35888-3","model_system":"Fifty-seven people with recurrent calcium stones and hypocitraturia randomized to potassium citrate 30-60 mEq/day or placebo; three-year outcomes in 18 and 20 respectively.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [barcelo-1993-stones] Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis (1993). https://www.sciencedirect.com/science/article/pii/S0022534717358883 DOI: 10.1016/S0022-5347(17)35888-3","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}