{"id":"b8d82719-9f97-5b31-8c63-7dd129e80d5b","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:atorvastatin-ldl-cholesterol","predicate":"reduces","statement":"Sixteen weeks of atorvastatin reduced total cholesterol and low-density-lipoprotein cholesterol in type 2 diabetic patients with hypercholesterolaemia.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f203ccce-9d93-5b53-92ac-3c350336fce7","mechanism_event_label":"Sixteen weeks of atorvastatin reduced total cholesterol and low-density-lipoprotein cholesterol in type 2 diabetic patients with hypercholesterolaemia.","subject":{"id":"64f4b2c7-afdf-5b9a-b6f9-015a7aa96eee","slug":"atorvastatin","display_name":"Atorvastatin","entity_type_key":"small_molecule"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f203ccce-9d93-5b53-92ac-3c350336fce7","stable_key":"1fb6218a-60d1-55ea-87fe-07d15d0fc46f:atorvastatin-ldl-cholesterol-event","event_type":"observed_relationship","label":"Sixteen weeks of atorvastatin reduced total cholesterol and low-density-lipoprotein cholesterol in type 2 diabetic patients with hypercholesterolaemia.","description":"Sixteen weeks of atorvastatin reduced total cholesterol and low-density-lipoprotein cholesterol in type 2 diabetic patients with hypercholesterolaemia.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"64f4b2c7-afdf-5b9a-b6f9-015a7aa96eee","slug":"atorvastatin","display_name":"Atorvastatin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a8b5e5e1-b5b5-551d-8fd4-72f7b45de78a","slug":"hmgcr","display_name":"HMG-CoA reductase (HMGCR)","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"16 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"84 Japanese type 2 diabetic patients with hypercholesterolaemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Atorvastatin for 16 weeks, multicentre open-label","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Open-label and without a placebo arm, and responders were defined by reaching an LDL target rather than randomised.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"84 Japanese type 2 diabetic patients with hypercholesterolaemia","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Sixteen weeks of atorvastatin reduced total cholesterol and low-density-lipoprotein cholesterol in type 2 diabetic patients with hypercholesterolaemia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Atorvastatin lowers plasma low-density lipoprotein cholesterol and C-reactive protein in Japanese type 2 diabetic patients. 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(2006). https://pubmed.ncbi.nlm.nih.gov/16324921/ DOI: 10.1016/j.metabol.2005.07.017\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a4431d8c-34d7-5db7-9edf-a35f68feba39","stable_key":"import-1fb6218a-60d1-55ea-87fe-07d15d0fc46f","title":"Atorvastatin: mechanism of action from target occupancy to isoprenoids, transport, muscle and metabolism (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies resolved by PubMed title search and cross-checked against live PubMed metadata. Findings obtained with mevastatin, simvastatin or the statin class are recorded against those subjects. Study-specific citations, doses, negative findings and limitations retained. 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