{"id":"b88cec62-d9f8-5d9e-9c6b-f623c7a08a68","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-akt-survival","predicate":"inhibition_blocks","statement":"Pharmacological Akt inhibition abolished strontium protection against osteoblast apoptosis in the tested wild-type and Casr-knockout mouse cultures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ef9d2ade-0c3b-58f0-84d5-2cc36c4da2f6","mechanism_event_label":"A downstream survival pathway remained necessary even when the receptor was absent.","subject":{"id":"43dee7e1-274c-533f-89ea-c91521728a8f","slug":"mouse-akt-proteins","display_name":"Mouse Akt protein family (isoform unresolved)","entity_type_key":"protein_family"},"object":{"id":"63dfadc2-24e0-5af8-8a65-fe3d73e8c2ac","slug":"mouse-strontium-osteoblast-survival","display_name":"Strontium-associated survival of mouse osteoblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ef9d2ade-0c3b-58f0-84d5-2cc36c4da2f6","stable_key":"1ff3a29f-ef80-5bff-9300-30b98c60b90d:strontium-akt-survival-event","event_type":"observed_relationship","label":"A downstream survival pathway remained necessary even when the receptor was absent.","description":"Pharmacological Akt inhibition abolished strontium protection against osteoblast apoptosis in the tested wild-type and Casr-knockout mouse cultures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"43dee7e1-274c-533f-89ea-c91521728a8f","slug":"mouse-akt-proteins","display_name":"Mouse Akt protein family (isoform unresolved)","entity_type_key":"protein_family"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"63dfadc2-24e0-5af8-8a65-fe3d73e8c2ac","slug":"mouse-strontium-osteoblast-survival","display_name":"Strontium-associated survival of mouse osteoblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2ca2864b-1ef0-54e4-8397-1dbe7207a0d2","slug":"strontium","display_name":"Strontium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"97607549-3a37-544e-b6e6-266887f7c35f","slug":"strontium-ion","display_name":"Strontium ion / Sr2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"18071fe3-a86f-5dac-b440-1e2e59d22f24","slug":"mouse-casr","display_name":"Mouse calcium-sensing receptor / Casr","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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