{"id":"b84cea61-9073-5112-8c0b-6805173a2360","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-peroxide-fgfr","predicate":"promotes","statement":"The phosphate-associated hydrogen-peroxide burst oxidized critical cysteine and methionine residues of FGFR1.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b3c4f330-a09f-5b59-9875-f282f91c68ab","mechanism_event_label":"A redox change reached the receptor protein.","subject":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"object":{"id":"2d65fff5-62ce-5e2d-8e3d-8df7336334f0","slug":"fgfr1-oxidation","display_name":"FGFR1 cysteine/methionine oxidation in the 2026 osteosarcoma study","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b3c4f330-a09f-5b59-9875-f282f91c68ab","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-peroxide-fgfr-event","event_type":"biochemical_relationship","label":"A redox change reached the receptor protein.","description":"The phosphate-associated hydrogen-peroxide burst oxidized critical cysteine and methionine residues of FGFR1.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6aa2a908-0a89-5ac7-91ca-c3a41fc292e3","slug":"fgfr1","display_name":"Fibroblast growth factor receptor 1 / FGFR1","entity_type_key":"protein"},"role":"modified_receptor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2d65fff5-62ce-5e2d-8e3d-8df7336334f0","slug":"fgfr1-oxidation","display_name":"FGFR1 cysteine/methionine oxidation in the 2026 osteosarcoma study","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/42247296.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Osteosarcoma-cell signaling with in-vivo tumor experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Elevated phosphate challenges and receptor activation experiments","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"New 2026 mechanism in tumor models; blood-Pi/tumor-growth association is not proof that dietary phosphorus causes human cancer. No specific transporter or oxidized residue number is invented from the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Osteosarcoma cellular and animal systems; precise species not fully resolved from abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A redox change reached the receptor protein.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p42247296] Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation. (2026). https://pubmed.ncbi.nlm.nih.gov/42247296/ DOI: 10.1016/j.celrep.2026.117504","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma-membrane/mitochondrial phosphate handling and FGFR1 signaling","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a2fb0327-ae7b-570b-b553-e0681c129356","evidence_kind":"source_excerpt","locator":"Lines 880-891","start_line":880,"end_line":891,"excerpt":"### phosphorus-peroxide-fgfr\nThe phosphate-associated hydrogen-peroxide burst oxidized critical cysteine and methionine residues of FGFR1.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A redox change reached the receptor protein.\norganism: Osteosarcoma cellular and animal systems; precise species not fully resolved from abstract\ntissue_or_cell_type: Plasma-membrane/mitochondrial phosphate handling and FGFR1 signaling\nexperimental_model: Osteosarcoma-cell signaling with in-vivo tumor experiments\nlimitations: New 2026 mechanism in tumor models; blood-Pi/tumor-growth association is not proof that dietary phosphorus causes human cancer. No specific transporter or oxidized residue number is invented from the abstract.\nexposure: Elevated phosphate challenges and receptor activation experiments\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/42247296.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\", \"start_char\": 0, \"end_char\": 1041, \"text_sha256\": \"a8d4221d8a5c56a5937ab8262e3ece5ed87692cb876ddcc0a08e7f68b66a9b76\"}\n[phosphorus-p42247296] Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation. (2026). https://pubmed.ncbi.nlm.nih.gov/42247296/ DOI: 10.1016/j.celrep.2026.117504","model_system":"Osteosarcoma-cell signaling with in-vivo tumor experiments","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [phosphorus-p42247296] Unconventional activation of the proto-oncogene FGFR1 by extracellular phosphate via H2O2-mediated kinase oxidation. (2026). https://pubmed.ncbi.nlm.nih.gov/42247296/ DOI: 10.1016/j.celrep.2026.117504","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"cfdefe70-3a09-5e2e-97c8-46626382e4b4","stable_key":"import-fe6af7fc-7372-5c4f-9c2f-2bbf56695397","title":"Phosphorus: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a04956d7177582b749608db404e6b691ae3b28a9f2f762781b6d820b461044fb","revision_id":"713b78f5-1133-5b2b-8822-20c0852e3715","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}