{"id":"b7f37243-81e2-57cf-80d3-cbd96515456f","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-excretion","predicate":"shows_slow_serum_clearance","statement":"The fitted serum elimination half-times averaged about 4.7 and 4.6 days in the 50- and 100-mg elemental-V/day groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b42f6b86-971c-5ea2-a6d3-4cb180c7fe06","mechanism_event_label":"Metal handling continues beyond the last swallowed dose.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"7ae2ebb5-6d9b-554f-8aa4-8d105b3f7e3a","slug":"human-vanadium-serum-elimination","display_name":"Serum vanadium elimination after sulfate exposure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b42f6b86-971c-5ea2-a6d3-4cb180c7fe06","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-excretion-event","event_type":"observed_relationship","label":"Metal handling continues beyond the last swallowed dose.","description":"The fitted serum elimination half-times averaged about 4.7 and 4.6 days in the 50- and 100-mg elemental-V/day groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7ae2ebb5-6d9b-554f-8aa4-8d105b3f7e3a","slug":"human-vanadium-serum-elimination","display_name":"Serum vanadium elimination after sulfate exposure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same cohort; one-compartment first-order model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Elemental V amounts differ from sulfate mass; fitted serum kinetics are not every tissue’s clearance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"Metal handling continues beyond the last swallowed dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Coordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a38eba7d-aaed-51cb-aad9-183ef4eaf1d1","evidence_kind":"source_excerpt","locator":"Lines 422-428","start_line":422,"end_line":428,"excerpt":"## vanadium-human-excretion\nMetal handling continues beyond the last swallowed dose.\nThe fitted serum elimination half-times averaged about 4.7 and 4.6 days in the 50- and 100-mg elemental-V/day groups.\nModel: Same cohort; one-compartment first-order model.\nLimitations: Elemental V amounts differ from sulfate mass; fitted serum kinetics are not every tissue’s clearance.\nEvidence access: Primary full text\nCoordination chemistry may explain pharmacokinetics and clinical response of vanadyl sulfate in type 2 diabetic patients. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23982218/ · DOI 10.1039/c3mt00162h","model_system":"Same cohort; one-compartment first-order model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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