{"id":"b7e94079-7f15-517b-bdc0-c72a70db536b","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-iron-sequestration","predicate":"deficiency_changes","statement":"Vitamin A-deficient rats had more splenic iron but lower serum iron and transferrin saturation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"83c6364c-8ff5-5f6d-b1c8-e6fc433b39a5","mechanism_event_label":"Iron could be retained in one tissue while circulating availability fell.","subject":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"object":{"id":"f2aa2773-67a1-516b-bfa8-661eb64c2517","slug":"spleen-iron-storage","display_name":"Splenic iron storage","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"83c6364c-8ff5-5f6d-b1c8-e6fc433b39a5","stable_key":"dff9f743-3766-5f20-a71e-d6d2bd5bfb6f:va-deficiency-iron-sequestration-event","event_type":"biochemical_relationship","label":"Iron could be retained in one tissue while circulating availability fell.","description":"Vitamin A-deficient rats had more splenic iron but lower serum iron and transferrin saturation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"62f35ef9-e8bf-5b02-85f8-bc2f281f30dd","slug":"serum-iron-concentration","display_name":"Serum iron concentration","entity_type_key":"cellular_process"},"role":"decreased_marker","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ce392c9e-6483-5914-b18b-d6a2520dbbf6","slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f2aa2773-67a1-516b-bfa8-661eb64c2517","slug":"spleen-iron-storage","display_name":"Splenic iron storage","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [va-cunha2014] Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis (2014). https://pubmed.ncbi.nlm.nih.gov/24998947/ DOI: 10.1016/j.jnutbio.2014.05.005","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0c5474e2-be48-547b-b287-9c07a59c9ff1","stable_key":"import-dff9f743-3766-5f20-a71e-d6d2bd5bfb6f","title":"Vitamin A: forms, mechanisms, deficiency and excess (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b217224b262abbd77d6a0c8c9beefff9c022fae4d31e2a5273915d769b9a6546","revision_id":"61008909-871f-575c-b5e2-21542689ea3c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}