{"id":"b7cb1b6e-d732-5a40-bac9-2367edcb5b2f","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-mpo-ldl","predicate":"inhibits","statement":"Betanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"4423d056-704b-518f-90d4-4135a102442f","mechanism_event_label":"Betanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.","subject":{"id":"6c12bb61-c9c2-5c6d-a087-a292145ccaf0","slug":"betanin","display_name":"Betanin","entity_type_key":"small_molecule"},"object":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4423d056-704b-518f-90d4-4135a102442f","stable_key":"cab605fe-8a82-5191-9966-d19a9628c24c:betalains-mpo-ldl-event","event_type":"observed_relationship","label":"Betanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.","description":"Betanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6c12bb61-c9c2-5c6d-a087-a292145ccaf0","slug":"betanin","display_name":"Betanin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f00627d2-4857-5c63-81af-71cde3768d38","slug":"lipid-peroxidation","display_name":"Lipid peroxidation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"53f51828-4ea1-5f2e-a044-e02577272436","slug":"mpo","display_name":"Human myeloperoxidase / MPO","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"03ffed32-aa18-5d63-96a4-8a7ebedaf7a9","slug":"nitrite","display_name":"Nitrite / NO2(-)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"19901d14-1463-5a22-b2f5-afdfb70a7a23","slug":"ldl-particles","display_name":"Low-density lipoprotein particles; preparation specified","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Experimental betanin addition; concentration not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Oxidation time courses; duration not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; detailed exposure for PMID 23931157 additionally checked in publisher results. No uninspected full text is claimed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated human LDL and MPO/nitrite biochemical system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Oxidation products were not chemically identified; clinical LDL lowering was not tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Betalains collection; each molecular form, species, exposure and preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"betalains","display_name":"Betalains","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Isolated human LDL and MPO/nitrite biochemical system","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Betanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. (2007). https://pubmed.ncbi.nlm.nih.gov/17364963/ DOI: 10.1080/10715760601038783","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"LDL lipid compartment","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"873ece11-0cb6-5c17-b7c9-7dc341727df5","evidence_kind":"source_excerpt","locator":"Lines 187-195","start_line":187,"end_line":195,"excerpt":"## betalains-mpo-ldl\nBetanin reduced lipid hydroperoxide formation during MPO/nitrite-mediated oxidation of human LDL.\nModel/species: Isolated human LDL and MPO/nitrite biochemical system\nTissue: LDL lipid compartment\nExposure: Experimental betanin addition; concentration not specified in accessed abstract\nRoute: In vitro addition\nDuration: Oxidation time courses; duration not specified in accessed abstract\nLimits: Oxidation products were not chemically identified; clinical LDL lowering was not tested.\nPrimary reference: Betanin inhibits the myeloperoxidase/nitrite-induced oxidation of human low-density lipoproteins. (2007). https://pubmed.ncbi.nlm.nih.gov/17364963/ DOI: 10.1080/10715760601038783","model_system":"Isolated human LDL and MPO/nitrite biochemical system","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; an original paraphrase with an individually identified primary reference.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"be94d093-444c-5729-8831-bc33b0ef2fd7","stable_key":"import-cab605fe-8a82-5191-9966-d19a9628c24c","title":"Betalains: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary research papers; study-specific PubMed/DOI links and limitations retained. 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