{"id":"b7ac0f63-8c04-5cd8-acbd-9f3797f6c2a1","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-combined-shortage","predicate":"is_part_of_restricted_supply_in","statement":"An infant treated for tyrosinemia type I developed growth failure, anorexia, lethargy and hypotonia with low phenylalanine and tyrosine during restriction; adding both amino acids reversed these manifestations without reversing cirrhosis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"04d3d1ce-12cd-501b-8596-bb754927bbe7","mechanism_event_label":"Over-restricting these building blocks can create a new shortage problem.","subject":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"object":{"id":"5732ff52-f911-58c9-b8dd-5edc3a510d86","slug":"infant-phe-tyr-restriction-syndrome","display_name":"Infant illness during combined phenylalanine and tyrosine restriction","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"04d3d1ce-12cd-501b-8596-bb754927bbe7","stable_key":"56f1d914-e7da-595a-af69-c217b2b47407:l-phenylalanine-combined-shortage-event","event_type":"observed_relationship","label":"Over-restricting these building blocks can create a new shortage problem.","description":"An infant treated for tyrosinemia type I developed growth failure, anorexia, lethargy and hypotonia with low phenylalanine and tyrosine during restriction; adding both amino acids reversed these manifestations without reversing cirrhosis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"190407ad-0219-54b5-b05f-7c75f3895ca6","slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5732ff52-f911-58c9-b8dd-5edc3a510d86","slug":"infant-phe-tyr-restriction-syndrome","display_name":"Infant illness during combined phenylalanine and tyrosine restriction","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bcfef85f-831d-5439-ba51-1aef4b090441","slug":"l-tyrosine","display_name":"L-Tyrosine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single historical infant case with combined phenylalanine/tyrosine restriction and repletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cannot attribute every manifestation to isolated phenylalanine deficiency or generalize a dose threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Phenylalanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"l-phenylalanine","display_name":"L-Phenylalanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Over-restricting these building blocks can create a new shortage problem.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Phenylalanine-tyrosine deficiency syndrome as a complication of the management of hereditary tyrosinemia. · 1977 · https://pubmed.ncbi.nlm.nih.gov/835507/ · DOI 10.1093/ajcn/30.2.209","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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