{"id":"b7825ade-51af-5b90-b59c-2ecb57780a4d","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-isoproterenol","predicate":"potentiates","statement":"Co-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"ea14bdef-03df-507b-ae24-d3600e8a39f8","mechanism_event_label":"Co-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.","subject":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"13ce77df-f4f2-57ed-a48f-0912c6ebc1a0","slug":"human-airway-isoproterenol-relaxation","display_name":"Isoproterenol-induced relaxation of human airway smooth muscle","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ea14bdef-03df-507b-ae24-d3600e8a39f8","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-isoproterenol-event","event_type":"observed_relationship","label":"Co-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.","description":"Co-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"13ce77df-f4f2-57ed-a48f-0912c6ebc1a0","slug":"human-airway-isoproterenol-relaxation","display_name":"Isoproterenol-induced relaxation of human airway smooth muscle","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"a6746af5-8396-5d4a-af6d-73bfa9b340d8","slug":"isoproterenol","display_name":"Isoproterenol","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"6- or 8-gingerol 100 micromolar with isoproterenol concentration-response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Acute relaxation assay; exact duration not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human airway smooth muscle tissue in organ baths","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"High experimental parent-compound exposure; not clinical inhaler potentiation or a recommended co-treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human airway smooth muscle tissue in organ baths","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Co-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo tissue bath","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Airway smooth muscle","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"444ad425-12a0-5260-a8e8-afc0b2f25c38","evidence_kind":"source_excerpt","locator":"Lines 206-215","start_line":206,"end_line":215,"excerpt":"## gingerols-8-isoproterenol\nCo-applying 8-gingerol enhanced isoproterenol-induced relaxation of isolated human airway smooth muscle.\nModel/species: Human airway smooth muscle tissue in organ baths\nTissue: Airway smooth muscle\nExposure: 6- or 8-gingerol 100 micromolar with isoproterenol concentration-response\nRoute: Ex vivo tissue bath\nDuration: Acute relaxation assay; exact duration not in accessed abstract\nLimits: High experimental parent-compound exposure; not clinical inhaler potentiation or a recommended co-treatment.\nPrimary reference: Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteins. (2014). https://pubmed.ncbi.nlm.nih.gov/23962082/ DOI: 10.1165/rcmb.2013-0133OC\nAccess: Primary PubMed abstract.","model_system":"Human airway smooth muscle tissue in organ baths","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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