{"id":"b72e2e85-564d-585f-8d21-e721f6265046","stable_key":"research:selenow-interacts-14-3-3","predicate":"interacts_with","statement":"SELENOW interacts with 14-3-3 beta in the reported cultured-cell redox and thioredoxin-perturbation experiments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"literature_reviewed:direct_experimental","direction":"positive","is_public":true,"mechanism_event_id":"fae75ba5-02cb-55a4-9475-13a21bdfdf1a","mechanism_event_label":"SELENOW interacts with a signaling-regulator protein called 14-3-3 beta.","subject":{"id":"4a52fead-0d17-55b2-8663-7408d7488416","slug":"selenow","display_name":"SELENOW","entity_type_key":"protein"},"object":{"id":"83488c45-ae9d-5d9a-8ed8-15811efc5e62","slug":"ywhab","display_name":"YWHAB","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"fae75ba5-02cb-55a4-9475-13a21bdfdf1a","stable_key":"research:selenow-interacts-14-3-3","event_type":"experimentally_scoped_interaction","label":"SELENOW interacts with a signaling-regulator protein called 14-3-3 beta.","description":"SELENOW interacts with 14-3-3 beta in the reported cultured-cell redox and thioredoxin-perturbation experiments.","status":"active","compartment":null,"participants":[{"entity":{"id":"4a52fead-0d17-55b2-8663-7408d7488416","slug":"selenow","display_name":"SELENOW","entity_type_key":"protein"},"role":"regulator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"83488c45-ae9d-5d9a-8ed8-15811efc5e62","slug":"ywhab","display_name":"YWHAB","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Cultured-cell protein interactions and etoposide/thioredoxin perturbations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The tested interaction is not a complete physiological substrate map or proof that all selenium-responsive processes use this partner.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"Cultured mammalian cells","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8e579b39-7f3b-5937-8322-5f1c7d569a9a","evidence_kind":"curated_literature_summary","locator":"lines 1108-1117","start_line":1108,"end_line":1117,"excerpt":"## selenow-interacts-14-3-3\n\nSELENOW interacts with a signaling-regulator protein called 14-3-3 beta.\n\nSELENOW interacts with 14-3-3 beta in the reported cultured-cell redox and thioredoxin-perturbation experiments.\n\nExperimental model: Cultured-cell protein interactions and etoposide/thioredoxin perturbations.\nOrganism: Cultured mammalian cells\nLimitations: The tested interaction is not a complete physiological substrate map or proof that all selenium-responsive processes use this partner.\nPrimary reference: [Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3](https://pmc.ncbi.nlm.nih.gov/articles/PMC8508763/)","model_system":"Cultured-cell protein interactions and etoposide/thioredoxin perturbations.","directness":"author_interpretation","verification_status":"secondary_verified","notes":"Curated summary; inspect the linked primary papers for original methods and results.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4f892f13-06ea-5199-a33c-a703f35c80ae","stable_key":"selenium-research-2026-09-17","title":"Selenium: literature corrections and mechanism additions","document_type":"curated_literature_review","citation_label":"Metabolic Ledger literature curation, 17 September 2026; primary papers linked individually","file_path":"","sha256":"0b818b10c1c7120e5caf7f4d4019d7bd025d745692e424f515d3ef903c9ab7f3","revision_id":"80984e03-5f0f-5877-8094-afef7637444e","review_status":"secondary_verified","notes":"Secondary curated summaries of primary experiments, with explicit models and limitations. Not archived primary full text."}}],"relations":[],"conflicts":[],"corrections":[],"research":{"topic":"Protein regulation","plain_language":"SELENOW interacts with a signaling-regulator protein called 14-3-3 beta.","evidence_scope":"direct_experimental","papers":[{"key":"catalog-selenow-2021","title":"Compensatory Protection of Thioredoxin-Deficient Cells from Etoposide-Induced Cell Death by Selenoprotein W via Interaction with 14-3-3","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8508763/","doi":null,"year":2021,"model":"Cultured-cell protein interactions and etoposide/thioredoxin perturbations.","summary":"Documents SELENOW interaction with 14-3-3 beta under the tested redox conditions."}]}}