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Cellular enzyme activity does not prove clinical cancer benefit.\nexposure: Rat enzyme: two-hour incubation, IC50 3.6 micromolar; HeLa activity IC50 about 15 micromolar\nevidence_span: {\"source_cache\": \"artifacts/curcumin-research/15879598.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c\", \"start_char\": 0, \"end_char\": 1659, \"text_sha256\": \"be68f9ed2b0741db356a6bc020304fe832121f92dfd9c423ce8a305e984e995c\"}\n[curcumin-p15879598] Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity. 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