{"id":"b7005cbd-b862-501e-9c2f-56819591bcfc","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-xct-cystine","predicate":"transports_with_4f2hc","statement":"Human hxCTb required 4F2hc for sodium-independent cystine/glutamate transport in oocytes.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"0a1170c9-cd8f-58da-af41-b1466752d048","mechanism_event_label":"The precursor-entry route depends on two transporter subunits.","subject":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"object":{"id":"cdd84f4d-3e8f-502a-a8c5-19672cc5346f","slug":"cystine","display_name":"Cystine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"0a1170c9-cd8f-58da-af41-b1466752d048","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-xct-cystine-event","event_type":"biochemical_relationship","label":"The precursor-entry route depends on two transporter subunits.","description":"Human hxCTb required 4F2hc for sodium-independent cystine/glutamate transport in oocytes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1ca4b4d5-616a-54d3-8244-0dc151b1bcfe","slug":"slc3a2","display_name":"4F2hc / SLC3A2","entity_type_key":"protein"},"role":"required_partner","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"exchange_substrate","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"aac19cc3-1b68-5ca3-a896-f61184f7320a","slug":"slc7a11","display_name":"SLC7A11","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"cdd84f4d-3e8f-502a-a8c5-19672cc5346f","slug":"cystine","display_name":"Cystine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/11406111.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e7118afd8c6055ed926ee24dbb7a07538f676163d605115ae0d32d49fbef7fdc\", \"start_char\": 0, \"end_char\": 1364, \"text_sha256\": \"e7118afd8c6055ed926ee24dbb7a07538f676163d605115ae0d32d49fbef7fdc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human xCT expression and oxidative-stress response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"hxCTb with 4F2hc; diethyl maleate challenge","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Sodium independence belongs to this transporter; other cysteine-entry routes differ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human transporter; Xenopus expression host","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The precursor-entry route depends on two transporter subunits.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p11406111] Human cystine/glutamate transporter: cDNA cloning and upregulation by oxidative stress in glioma cells. 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