{"id":"b6d550da-98d6-5770-bc60-44c977a61a2f","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-ttll7-neurite-loss","predicate":"supports_tested","statement":"Ttll7 siRNA in rat PC12 cells reduced nerve-growth-factor-stimulated MAP2-positive neurite growth.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"83b4dfd1-2b98-5379-ac6c-0fff86b5b453","mechanism_event_label":"A glutamate-chain-adding enzyme contributed to cell shape in a differentiation model.","subject":{"id":"ef2530c7-8184-5123-b836-6c84c7dd24ad","slug":"rat-ttll7","display_name":"Rat tubulin polyglutamylase / Ttll7","entity_type_key":"protein"},"object":{"id":"fceea335-988e-5ada-baa6-e13f9e59bb06","slug":"rat-pc12-map2-neurite-growth","display_name":"MAP2-positive neurite growth in rat PC12 cells","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"83b4dfd1-2b98-5379-ac6c-0fff86b5b453","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-ttll7-neurite-loss-event","event_type":"observed_relationship","label":"A glutamate-chain-adding enzyme contributed to cell shape in a differentiation model.","description":"Ttll7 siRNA in rat PC12 cells reduced nerve-growth-factor-stimulated MAP2-positive neurite growth.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef2530c7-8184-5123-b836-6c84c7dd24ad","slug":"rat-ttll7","display_name":"Rat tubulin polyglutamylase / Ttll7","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fceea335-988e-5ada-baa6-e13f9e59bb06","slug":"rat-pc12-map2-neurite-growth","display_name":"MAP2-positive neurite growth in rat PC12 cells","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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