{"id":"b6a45467-aa50-5756-b994-5f29d7810e4a","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-lactate-neurons","predicate":"stimulates","statement":"Lactate stimulated the activity of SFO GABAergic neurons.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a90440c9-cc8a-5989-b2a3-2780e278f088","mechanism_event_label":"Lactate can pass information from sodium-sensing glia to nearby neurons.","subject":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"object":{"id":"b34b62ce-24ed-536b-abf1-1e7870733ac5","slug":"sfo-gabaergic-neuron-firing","display_name":"Subfornical-organ GABAergic neuron activity","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a90440c9-cc8a-5989-b2a3-2780e278f088","stable_key":"195e8b84-ca5a-591a-a045-c55c53c8a01c:sodium-lactate-neurons-event","event_type":"biochemical_relationship","label":"Lactate can pass information from sodium-sensing glia to nearby neurons.","description":"Lactate stimulated the activity of SFO GABAergic neurons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5ebd9a7c-b151-5b70-b70d-7d33067d4ebf","slug":"lactate","display_name":"L-Lactate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b34b62ce-24ed-536b-abf1-1e7870733ac5","slug":"sfo-gabaergic-neuron-firing","display_name":"Subfornical-organ GABAergic neuron activity","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sodium-research/17408578.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5df7ccac391e94f2688ccacf287fda852b7a52e5279d1488ef48f0f52a3c6265\", \"start_char\": 0, \"end_char\": 953, \"text_sha256\": \"5df7ccac391e94f2688ccacf287fda852b7a52e5279d1488ef48f0f52a3c6265\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Protein interaction, glial metabolism and SFO neuronal recordings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Elevated sodium; Nax knockout; lactate exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Brain salt-sensing pathway in experimental preparations; not a human sodium-intake threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sodium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sodium","display_name":"Sodium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse SFO and mammalian cell preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Lactate can pass information from sodium-sensing glia to nearby neurons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sodium-p17408578] Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. (2007). https://pubmed.ncbi.nlm.nih.gov/17408578/ DOI: 10.1016/j.neuron.2007.03.014","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Glial cells and GABAergic neurons of the subfornical organ","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"51cb9846-42f3-5aba-8112-0ed4374dfcec","evidence_kind":"source_excerpt","locator":"Lines 473-484","start_line":473,"end_line":484,"excerpt":"### sodium-lactate-neurons\nLactate stimulated the activity of SFO GABAergic neurons.\nCondition category: normal\nnutrient_topic: Sodium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Lactate can pass information from sodium-sensing glia to nearby neurons.\norganism: Mouse SFO and mammalian cell preparations\ntissue_or_cell_type: Glial cells and GABAergic neurons of the subfornical organ\nexperimental_model: Protein interaction, glial metabolism and SFO neuronal recordings\nlimitations: Brain salt-sensing pathway in experimental preparations; not a human sodium-intake threshold.\nexposure: Elevated sodium; Nax knockout; lactate exposure\nevidence_span: {\"source_cache\": \"artifacts/sodium-research/17408578.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5df7ccac391e94f2688ccacf287fda852b7a52e5279d1488ef48f0f52a3c6265\", \"start_char\": 0, \"end_char\": 953, \"text_sha256\": \"5df7ccac391e94f2688ccacf287fda852b7a52e5279d1488ef48f0f52a3c6265\"}\n[sodium-p17408578] Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. (2007). https://pubmed.ncbi.nlm.nih.gov/17408578/ DOI: 10.1016/j.neuron.2007.03.014","model_system":"Protein interaction, glial metabolism and SFO neuronal recordings","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sodium-p17408578] Glial Nax channels control lactate signaling to neurons for brain [Na+] sensing. (2007). https://pubmed.ncbi.nlm.nih.gov/17408578/ DOI: 10.1016/j.neuron.2007.03.014","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c260cd7b-beb0-5113-a198-69ec8fd4492c","stable_key":"import-195e8b84-ca5a-591a-a045-c55c53c8a01c","title":"Sodium: gradients, nutrient transport, fluid regulation and loss states (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"684f65cf0661c18395831ade4b02bb24d5e66c568f0d00a3471600eaf5d4d1c6","revision_id":"39866f04-3052-5f59-bd95-6806c5490875","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}