{"id":"b680944d-7814-5ed5-8651-8d01623f9f5b","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pmn-peroxide","predicate":"reduces_measured_signal","statement":"KI suppressed the measured PMN-derived hydrogen-peroxide signal.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"dd6a6b44-39ac-551c-8b0f-3182ff99d2a0","mechanism_event_label":"KI lowered a peroxide assay readout in immune cells.","subject":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"object":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"dd6a6b44-39ac-551c-8b0f-3182ff99d2a0","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-pmn-peroxide-event","event_type":"observed_relationship","label":"KI lowered a peroxide assay readout in immune cells.","description":"KI suppressed the measured PMN-derived hydrogen-peroxide signal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d6a7fe6a-d90e-5fad-acf4-4971b24fa8d7","slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"da9d64bc-69d4-5d97-90a4-8f0ed03e0ac8","slug":"hydrogen-peroxide","display_name":"Hydrogen peroxide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay effects do not identify a unique molecular target or establish universal antioxidant action.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"KI lowered a peroxide assay readout in immune cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates. · 1982 · https://pubmed.ncbi.nlm.nih.gov/7104217/ · DOI 10.1111/j.1365-2133.1982.tb00340.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58d16111-6ba0-59d8-ac80-6e32e2aa2d8f","evidence_kind":"source_excerpt","locator":"Lines 288-294","start_line":288,"end_line":294,"excerpt":"## ki-pmn-peroxide\nKI lowered a peroxide assay readout in immune cells.\nKI suppressed the measured PMN-derived hydrogen-peroxide signal.\nModel: In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.\nLimitations: Assay effects do not identify a unique molecular target or establish universal antioxidant action.\nEvidence location: Primary abstract\nEffects of potassium iodide, colchicine and dapsone on the generation of polymorphonuclear leukocyte-derived oxygen intermediates. · 1982 · https://pubmed.ncbi.nlm.nih.gov/7104217/ · DOI 10.1111/j.1365-2133.1982.tb00340.x","model_system":"In-vitro polymorphonuclear leukocytes; tested drug concentrations reported as 10 micromolar–millimolar.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text.","file_path":"","sha256":"3ff9da818dd7a763a59c6abcff2eaee136d7f887a777034feaa5ba304a8fa6ce","revision_id":"53f2ae88-8a91-5326-ac49-3bb510ca78c3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}