{"id":"b6669dae-7504-5482-9fe6-9c1ebb877d15","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-standard-diet-mouse-survival","predicate":"did_not_extend","statement":"Resveratrol started at 12 months did not extend lifespan of ad-libitum standard-diet mice despite improvements in several age-associated outcomes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"78f0078d-4fca-5096-b7d3-5b640728b48c","mechanism_event_label":"Health-related changes and longevity are different endpoints.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"234b25ca-9db4-55be-969c-90bd260fea3b","slug":"mouse-standard-diet-lifespan","display_name":"Lifespan of standard-diet mice","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"78f0078d-4fca-5096-b7d3-5b640728b48c","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-standard-diet-mouse-survival-event","event_type":"observed_relationship","label":"Health-related changes and longevity are different endpoints.","description":"Resveratrol started at 12 months did not extend lifespan of ad-libitum standard-diet mice despite improvements in several age-associated outcomes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"234b25ca-9db4-55be-969c-90bd260fea3b","slug":"mouse-standard-diet-lifespan","display_name":"Lifespan of standard-diet mice","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Related mouse-aging research program.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Diet and start age differ from other lifespan designs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Health-related changes and longevity are different endpoints.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18599363/ · DOI 10.1016/j.cmet.2008.06.011","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e1bfb812-589d-56a0-81d4-493131d883eb","evidence_kind":"source_excerpt","locator":"Lines 502-508","start_line":502,"end_line":508,"excerpt":"## resveratrol-standard-diet-mouse-survival\nHealth-related changes and longevity are different endpoints.\nResveratrol started at 12 months did not extend lifespan of ad-libitum standard-diet mice despite improvements in several age-associated outcomes.\nModel: Related mouse-aging research program.\nLimitations: Diet and start age differ from other lifespan designs.\nEvidence access: Primary abstract\nResveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18599363/ · DOI 10.1016/j.cmet.2008.06.011","model_system":"Related mouse-aging research program.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"04885b4bee72f912a7f3f618f1b2bf79c944dbcb20500398c2729fc8228dcd9a","revision_id":"99504ff2-f1d3-5f4c-bc31-e1030d27a918","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}