{"id":"b662cd81-9784-5b16-b178-a975cbe0f4b8","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-acarbose-glp1","predicate":"prolongs","statement":"Acarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"06e5a90a-e7bb-5fa6-b816-898b40ba9ba4","mechanism_event_label":"Acarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.","subject":{"id":"1e80f339-2691-5fb8-a722-053c6d9b4aa5","slug":"acarbose","display_name":"Acarbose","entity_type_key":"drug"},"object":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"06e5a90a-e7bb-5fa6-b816-898b40ba9ba4","stable_key":"c932089b-ebc9-5f39-b2e5-84af74f9f6d0:sucrose-acarbose-glp1-event","event_type":"observed_relationship","label":"Acarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.","description":"Acarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1e80f339-2691-5fb8-a722-053c6d9b4aa5","slug":"acarbose","display_name":"Acarbose","entity_type_key":"drug"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9086d887-f5ea-5dfb-a68f-adb2c2bda3c7","slug":"plasma-glp1-response","display_name":"Plasma GLP-1 response in the specified meal or glucose challenge","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"82558bd0-1a84-574a-a04c-10609c9c5dba","slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4853afc6-9eaa-547f-91d7-c4dd90082351","slug":"glp-1","display_name":"Glucagon-like peptide 1 / GLP-1","entity_type_key":"peptide"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Meal with 50 g added sucrose in 200 mL; with or without 100 mg acarbose before meal","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"GLP-1 through 60 minutes; ApoB-48 at 120 minutes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary full-text methods/results and metadata inspected.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; source-specific curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy Japanese men; 21 total, 12 in acarbose comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_scope","value_text":"Sucrose-containing mixed meal, drug and peptide response","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mixed meal includes starch, protein and fat. Association does not prove intact sucrose sensing by human L cells or GLP-1 mediation of ApoB-48; proposed paracrine mechanism remains a hypothesis.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sucrose chapter; direct sucrose observations are distinguished from shared component metabolism.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sucrose","display_name":"Sucrose","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Healthy Japanese men; 21 total, 12 in acarbose comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Acarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed meal and drug","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma active GLP-1 and ApoB-48 after mixed meal","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"73a574d6-88b3-5d99-96f3-844fc098df0e","evidence_kind":"source_excerpt","locator":"Lines 271-281","start_line":271,"end_line":281,"excerpt":"## sucrose-acarbose-glp1\nAcarbose pretreatment prolonged active GLP-1 elevation to 60 minutes after the sucrose-containing mixed meal.\nModel/species: Healthy Japanese men; 21 total, 12 in acarbose comparison\nTissue: Plasma active GLP-1 and ApoB-48 after mixed meal\nExposure: Meal with 50 g added sucrose in 200 mL; with or without 100 mg acarbose before meal\nRoute: Oral mixed meal and drug\nDuration: GLP-1 through 60 minutes; ApoB-48 at 120 minutes\nExposure scope: Sucrose-containing mixed meal, drug and peptide response\nLimits: Mixed meal includes starch, protein and fat. Association does not prove intact sucrose sensing by human L cells or GLP-1 mediation of ApoB-48; proposed paracrine mechanism remains a hypothesis.\nReference: Glucagon-like peptide-1 secretion by direct stimulation of L cells with luminal sugar vs non-nutritive sweetener. (2012). https://pubmed.ncbi.nlm.nih.gov/24843559/ DOI: 10.1111/j.2040-1124.2011.00163.x\nAccess: Primary full-text methods/results and metadata inspected.","model_system":"Healthy Japanese men; 21 total, 12 in acarbose comparison","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span, not a publisher quotation; provenance retained.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"8e24ddf4-84ee-57b4-9fd8-093547432ece","stable_key":"import-c932089b-ebc9-5f39-b2e5-84af74f9f6d0","title":"Sucrose: mechanism of action and metabolic impact (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific sucrose curation with shared canonical claims retained by identity. Primary-study citations, negative findings, exposure details and limitations preserved. Not publisher full text.","file_path":"","sha256":"5e68ccbade7a80fc03778495756f0eeeeba5038cd10d5bef8e33cb1e93e4b044","revision_id":"6edb8ffc-11c5-5cd9-852c-85adb71165a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}