{"id":"b64d339e-503b-5fc8-8d88-ba8f8d5d59c8","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:pat-hyperalgesia","predicate":"decreases_in_recorded_experiment","statement":"The PAT analogue reduced experimental hyperalgesia in rats with changes in inflammatory mediators; this is not native-thymulin analgesic efficacy in humans.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"e2d3fefe-646e-5c34-b00d-32c1a0154906","mechanism_event_label":"The PAT analogue reduced experimental hyperalgesia in rats with changes in inflammatory mediators; this is not native-thymulin analgesic efficacy in humans.","subject":{"id":"5d592640-3c0b-5efd-82d6-3d0fb45a951f","slug":"pat-thymulin-analogue","display_name":"PAT thymulin peptide analogue","entity_type_key":"peptide"},"object":{"id":"e545e7fc-fd87-58db-8551-d2e3e9228285","slug":"rat-hyperalgesia","display_name":"Rat experimental hyperalgesia","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e2d3fefe-646e-5c34-b00d-32c1a0154906","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:pat-hyperalgesia-event","event_type":"experimental_observation","label":"The PAT analogue reduced experimental hyperalgesia in rats with changes in inflammatory mediators; this is not native-thymulin analgesic efficacy in humans.","description":"Native peptide, zinc-loaded preparation, engineered met-FTS expression, PAT and nanoparticles are separate interventions. The PAT rat study supports anti-hyperalgesic activity for that **analogue**, with changes in inflammatory mediators; it does not establish analgesic efficacy of native thymulin in people. [PAT study](https://pubmed.ncbi.nlm.nih.gov/12110619/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5d592640-3c0b-5efd-82d6-3d0fb45a951f","slug":"pat-thymulin-analogue","display_name":"PAT thymulin peptide analogue","entity_type_key":"peptide"},"role":"tested factor","stoichiometry":null,"state_label":"PAT analogue","sequence_order":0,"notes":""},{"entity":{"id":"e545e7fc-fd87-58db-8551-d2e3e9228285","slug":"rat-hyperalgesia","display_name":"Rat experimental hyperalgesia","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"PAT analogue\", \"comparator\": \"Experimental control\", \"endpoint\": \"The PAT analogue reduced experimental hyperalgesia in rats with changes in inflammatory mediators; this is not native-thymulin analgesic efficacy in humans.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Rat PAT experiment; analogue kept separate from native peptide and withdrawn hippocampal PAT article.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The PAT analogue reduced experimental hyperalgesia in rats with changes in inflammatory mediators; this is not native-thymulin analgesic efficacy in humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Potent analgesic and anti-inflammatory actions of a novel thymulin-related peptide in the rat. | 2002 | DOI 10.1038/sj.bjp.0704793 | PMID 12110619 | https://pubmed.ncbi.nlm.nih.gov/12110619/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 150-150; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"72ef0fca-4d66-5858-b36a-42d1478aaf12","evidence_kind":"source_excerpt","locator":"Lines 150-150","start_line":150,"end_line":150,"excerpt":"Native peptide, zinc-loaded preparation, engineered met-FTS expression, PAT and nanoparticles are separate interventions. The PAT rat study supports anti-hyperalgesic activity for that **analogue**, with changes in inflammatory mediators; it does not establish analgesic efficacy of native thymulin in people. [PAT study](https://pubmed.ncbi.nlm.nih.gov/12110619/)","model_system":"Rat PAT experiment; analogue kept separate from native peptide and withdrawn hippocampal PAT article.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e1871d49-9c6b-547b-a1bb-6e2b9270ca89","stable_key":"import-18100170-a014-51c3-adeb-9dab4162b8cc","title":"Thymulin: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"6e8ed0d7a5e23fc822f2ab418e0c4fb2411c01fcaa330039e8d7d93218cacc88","revision_id":"8c0e3449-9bbd-57c0-bb5e-de83f044f2ac","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}