{"id":"b64280ff-5b9d-582d-8330-c27a97c72c40","stable_key":"availability:uneven-selenoprotein-response:2","predicate":"can_reduce_expression_of","statement":"SELENOW expression is sensitive to selenium restriction and translation regulation in experimental systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"source_reported: Animal model and cell/biochemical; source-derived unverified synthesis.","direction":"negative","is_public":true,"mechanism_event_id":"fc27c4fa-cdf4-5bfb-891e-07581428792b","mechanism_event_label":"SELENOW expression is sensitive to selenium restriction and translation regulation in experimental systems.","subject":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"object":{"id":"4a52fead-0d17-55b2-8663-7408d7488416","slug":"selenow","display_name":"SELENOW","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"fc27c4fa-cdf4-5bfb-891e-07581428792b","stable_key":"availability:uneven-selenoprotein-response:2","event_type":"availability_dependent_change","label":"SELENOW expression is sensitive to selenium restriction and translation regulation in experimental systems.","description":"Selenium supply is restricted for a defined tissue, species, and duration. Predominantly animal and cell models; ranking varies with tissue, species, development, duration, and measurement.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"dc89d7e2-8f89-577b-838f-42bf5d8ec7c8","slug":"selenium","display_name":"Selenium","entity_type_key":"nutrient_element"},"role":"condition_input","stoichiometry":null,"state_label":"Selenium supply is restricted for a defined tissue, species, and duration.","sequence_order":0,"notes":""},{"entity":{"id":"4a52fead-0d17-55b2-8663-7408d7488416","slug":"selenow","display_name":"SELENOW","entity_type_key":"protein"},"role":"affected_component","stoichiometry":null,"state_label":"Selenium supply is restricted for a defined tissue, species, and duration.","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"Selenium supply is restricted for a defined tissue, species, and duration.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_scope","value_text":"Predominantly animal and cell models; ranking varies with tissue, species, development, duration, and measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Relative preservation does not mean immunity to severe loss. Um34 alone does not implement a universal ranking, and no plasma-to-protein cutoff is assigned.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"14c88436-029d-5849-b266-06acd8aeda30","evidence_kind":"source_passage","locator":"lines 295-297","start_line":295,"end_line":297,"excerpt":"SELENOW expression ↓\n\nSensitive to selenium and tRNA/translation regulation in experimental systems","model_system":"Supplied reference; verify the primary study and experimental context.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c788c19c-884c-5233-92b1-0bd063d87741","stable_key":"deficiency","title":"Selenium deficiency: a mechanism-first reference","document_type":"user_supplied_reference","citation_label":"Supplied selenium deficiency reference","file_path":"X:\\metabolic-ledger\\source_material\\selenium-deficiency-reference.md","sha256":"a3f14bc3fa24c595dda830664523090a7b5bfa76e9dcf517f42f62212ceb767e","revision_id":"f8f97804-c1fb-56df-9c06-c02e36e2a5b8","review_status":"unverified_draft","notes":"Preserved verbatim. Reported study types are source labels, not independent verification."}}],"relations":[],"conflicts":[],"corrections":[],"research":null}