{"id":"b5c3e746-7e4f-5554-b311-1158e23cef9a","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-male-mouse-brain-aging","predicate":"preserves","statement":"Ergothioneine-treated aging male mice showed preserved learning/memory with changes in neurogenesis, TDP43 aggregation and microglial phenotype.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"e4d0887c-3410-55af-a7f6-cfece6dd2fe6","mechanism_event_label":"Several brain changes accompanied the behavioral result.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"818d154b-805a-515a-ae0d-2c62d38d289b","slug":"male-mouse-ergo-hippocampal-aging","display_name":"Male-mouse hippocampal aging outcomes during ergothioneine intake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e4d0887c-3410-55af-a7f6-cfece6dd2fe6","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-male-mouse-brain-aging-event","event_type":"observed_relationship","label":"Several brain changes accompanied the behavioral result.","description":"Ergothioneine-treated aging male mice showed preserved learning/memory with changes in neurogenesis, TDP43 aggregation and microglial phenotype.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"818d154b-805a-515a-ae0d-2c62d38d289b","slug":"male-mouse-ergo-hippocampal-aging","display_name":"Male-mouse hippocampal aging outcomes during ergothioneine intake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same lifelong mouse experiment as the lifespan record.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"These associations do not identify one necessary mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Several brain changes accompanied the behavioral result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine promotes longevity and healthy aging in male mice. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38446314/ · DOI 10.1007/s11357-024-01111-5","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"aa278cc3-6a81-594b-9e54-dcc27f493deb","evidence_kind":"source_excerpt","locator":"Lines 520-526","start_line":520,"end_line":526,"excerpt":"## ergothioneine-male-mouse-brain-aging\nSeveral brain changes accompanied the behavioral result.\nErgothioneine-treated aging male mice showed preserved learning/memory with changes in neurogenesis, TDP43 aggregation and microglial phenotype.\nModel: Same lifelong mouse experiment as the lifespan record.\nLimitations: These associations do not identify one necessary mediator.\nEvidence access: Primary abstract\nErgothioneine promotes longevity and healthy aging in male mice. · 2024 · https://pubmed.ncbi.nlm.nih.gov/38446314/ · DOI 10.1007/s11357-024-01111-5","model_system":"Same lifelong mouse experiment as the lifespan record.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}