{"id":"b59cc1ac-cfb6-5ed6-a210-6fe2564d106c","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-ca","predicate":"reduces","statement":"Calcium reabsorption fell from 98.6% to 97.5%, with no significant change in filtered calcium load.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"f3753e9f-1fd8-534f-bf79-c2775e1f30d0","mechanism_event_label":"The kidneys retained a smaller fraction of the filtered mineral.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"9cee0b8f-f680-57b8-aac6-90ed927bd13b","slug":"renal-calcium-reabsorption","display_name":"Renal calcium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f3753e9f-1fd8-534f-bf79-c2775e1f30d0","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-ca-event","event_type":"observed_relationship","label":"The kidneys retained a smaller fraction of the filtered mineral.","description":"Calcium reabsorption fell from 98.6% to 97.5%, with no significant change in filtered calcium load.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9cee0b8f-f680-57b8-aac6-90ed927bd13b","slug":"renal-calcium-reabsorption","display_name":"Renal calcium reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute renal handling. The exact tubular mechanism was unresolved; no long-term deficiency, bone loss or replacement requirement measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The kidneys retained a smaller fraction of the filtered mineral.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b626700e-1219-548e-9eb1-4dc23963f9bb","evidence_kind":"source_excerpt","locator":"Lines 284-290","start_line":284,"end_line":290,"excerpt":"## caf-renal-ca\nThe kidneys retained a smaller fraction of the filtered mineral.\nCalcium reabsorption fell from 98.6% to 97.5%, with no significant change in filtered calcium load.\nModel: 37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.\nLimitations: Acute renal handling. The exact tubular mechanism was unresolved; no long-term deficiency, bone loss or replacement requirement measured.\nEvidence access: Primary abstract\nEffects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","model_system":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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