{"id":"b56f6efe-387e-5adf-955c-c9b202f3851f","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-fibroblast-transporter","predicate":"supports_import","statement":"SLC38A2 mediated alanine and glutamine uptake in human lung fibroblasts and increased with TGF-beta exposure or alanine deprivation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d8d039e7-a743-5779-9c8b-643184b60560","mechanism_event_label":"A shared importer links access to two amino acids.","subject":{"id":"d892d59f-d137-5a53-9b16-10e4b6732951","slug":"slc38a2","display_name":"Human sodium-coupled neutral amino acid transporter 2 / SLC38A2","entity_type_key":"protein"},"object":{"id":"26879820-7051-549b-ab29-1970e993ce9d","slug":"human-lung-fibroblast-alanine","display_name":"Alanine availability in human lung fibroblasts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"d8d039e7-a743-5779-9c8b-643184b60560","stable_key":"10aa417f-4b03-599f-a453-4aa09edeb27c:alanine-fibroblast-transporter-event","event_type":"observed_relationship","label":"A shared importer links access to two amino acids.","description":"SLC38A2 mediated alanine and glutamine uptake in human lung fibroblasts and increased with TGF-beta exposure or alanine deprivation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d892d59f-d137-5a53-9b16-10e4b6732951","slug":"slc38a2","display_name":"Human sodium-coupled neutral amino acid transporter 2 / SLC38A2","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"26879820-7051-549b-ab29-1970e993ce9d","slug":"human-lung-fibroblast-alanine","display_name":"Alanine availability in human lung fibroblasts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ebdc4461-c059-563e-88b0-422c21fdaa25","slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8637bb39-2c30-5168-baaf-3e613d831db0","slug":"glutamine","display_name":"L-Glutamine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"694a1fe3-07ac-5edf-a81e-96730001a3d2","slug":"tgfb1","display_name":"Transforming growth factor beta 1","entity_type_key":"cytokine"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"38de8704-84db-5770-ac1d-242cd787e798","slug":"sodium-ion","display_name":"Sodium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Normal and IPF human lung fibroblast transporter experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dual transport does not by itself prove clinically relevant competition at ordinary plasma concentrations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Alanine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"alanine","display_name":"L-Alanine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A shared importer links access to two amino acids.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"TGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42024472/ · DOI 10.1172/jci.insight.199449","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"47b6497d-c4bc-517e-aeb8-9d1645e989dd","evidence_kind":"source_excerpt","locator":"Lines 504-510","start_line":504,"end_line":510,"excerpt":"## alanine-fibroblast-transporter\nA shared importer links access to two amino acids.\nSLC38A2 mediated alanine and glutamine uptake in human lung fibroblasts and increased with TGF-beta exposure or alanine deprivation.\nModel: Normal and IPF human lung fibroblast transporter experiments.\nLimitations: Dual transport does not by itself prove clinically relevant competition at ordinary plasma concentrations.\nEvidence access: Primary full text\nTGF-β coordinates alanine synthesis and import for myofibroblast differentiation in pulmonary fibrosis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/42024472/ · DOI 10.1172/jci.insight.199449","model_system":"Normal and IPF human lung fibroblast transporter experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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Not publisher full text.","file_path":"","sha256":"8ce7dd76c88b2e25fa23d93f9655a244aadb9d90f55ec8b18ecf0fd4625a61d2","revision_id":"4ed32258-0213-599a-a272-6f8f62280773","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}