{"id":"b5688980-694d-578e-8352-74c611323970","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-chloride-salt-pressure","predicate":"increases_short_term","statement":"Potassium chloride and sodium chloride increased home systolic pressure versus placebo in the CKD crossover.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"529f2dea-db95-5ac9-a64a-764b66645dc5","mechanism_event_label":"The pressure response differed from trials in people with better kidney function.","subject":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"529f2dea-db95-5ac9-a64a-764b66645dc5","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-ckd-chloride-salt-pressure-event","event_type":"observed_intervention","label":"The pressure response differed from trials in people with better kidney function.","description":"Potassium chloride and sodium chloride increased home systolic pressure versus placebo in the CKD crossover.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f3fe99b8-4e4a-57cd-9a86-3651092c9f6c","slug":"sodium-chloride","display_name":"Sodium chloride","entity_type_key":"chemical_species"},"role":"parallel_comparator","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6f35aa38-f875-5759-b749-97a2f6480ff3","slug":"chloride-ion","display_name":"Chloride ion","entity_type_key":"ion"},"role":"shared_anion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9a56258e-7dda-5b6a-9a14-58c9fe1856c3","slug":"potassium-chloride","display_name":"Potassium chloride","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Chloride salt/kidney context -> pressure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same five-day periods.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Context difference, not proof of a universal adverse potassium effect; molecular mediator unproven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The pressure response differed from trials in people with better kidney function.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-ckd-salts2026] Randomized Cross-Over Trial of Electrolyte, Acid-Base and Blood Pressure Effects of Salt Supplements in CKD (2026). https://pubmed.ncbi.nlm.nih.gov/42381762/ DOI: 10.1016/j.ekir.2026.106619","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf0b1603-9bdd-50a9-87a8-fc321b82f6c5","evidence_kind":"source_excerpt","locator":"Lines 1685-1695","start_line":1685,"end_line":1695,"excerpt":"### k-ckd-chloride-salt-pressure\nPotassium chloride and sodium chloride increased home systolic pressure versus placebo in the CKD crossover.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The pressure response differed from trials in people with better kidney function.\norganism: Homo sapiens\ntissue_or_cell_type: Systemic circulation\nexperimental_model: Same five-day periods.\nlimitations: Context difference, not proof of a universal adverse potassium effect; molecular mediator unproven.\ncross_nutrient: Chloride salt/kidney context -> pressure.\n[k-ckd-salts2026] Randomized Cross-Over Trial of Electrolyte, Acid-Base and Blood Pressure Effects of Salt Supplements in CKD (2026). https://pubmed.ncbi.nlm.nih.gov/42381762/ DOI: 10.1016/j.ekir.2026.106619","model_system":"Same five-day periods.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-ckd-salts2026] Randomized Cross-Over Trial of Electrolyte, Acid-Base and Blood Pressure Effects of Salt Supplements in CKD (2026). https://pubmed.ncbi.nlm.nih.gov/42381762/ DOI: 10.1016/j.ekir.2026.106619","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}