{"id":"b55b9e21-3fef-5c5f-86c6-a9767ee024d7","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-adipogenesis","predicate":"inhibits","statement":"Astaxanthin opposed rosiglitazone-stimulated differentiation and lipid accumulation in mouse 3T3-L1 cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"1738715c-d1df-5b74-9c2c-659ab9da71b4","mechanism_event_label":"A stimulated fat-cell program was reduced in culture.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"11f6b3b9-ff4b-58e3-a057-33e54d76318a","slug":"mouse-astaxanthin-adipogenesis","display_name":"Rosiglitazone-stimulated mouse 3T3-L1 differentiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"1738715c-d1df-5b74-9c2c-659ab9da71b4","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-adipogenesis-event","event_type":"observed_relationship","label":"A stimulated fat-cell program was reduced in culture.","description":"Astaxanthin opposed rosiglitazone-stimulated differentiation and lipid accumulation in mouse 3T3-L1 cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"11f6b3b9-ff4b-58e3-a057-33e54d76318a","slug":"mouse-astaxanthin-adipogenesis","display_name":"Rosiglitazone-stimulated mouse 3T3-L1 differentiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse 3T3-L1 differentiation experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not show that astaxanthin inhibits every PPAR-gamma response or causes weight loss in people.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A stimulated fat-cell program was reduced in culture.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7192bc9e-612a-552c-9e75-b561c136ab23","evidence_kind":"source_excerpt","locator":"Lines 278-284","start_line":278,"end_line":284,"excerpt":"## astaxanthin-adipogenesis\nA stimulated fat-cell program was reduced in culture.\nAstaxanthin opposed rosiglitazone-stimulated differentiation and lipid accumulation in mouse 3T3-L1 cells.\nModel: Mouse 3T3-L1 differentiation experiment.\nLimitations: This does not show that astaxanthin inhibits every PPAR-gamma response or causes weight loss in people.\nEvidence access: Primary abstract\nAstaxanthin functions differently as a selective peroxisome proliferator-activated receptor γ modulator in adipocytes and macrophages. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22732454/ · DOI 10.1016/j.bcp.2012.05.021","model_system":"Mouse 3T3-L1 differentiation experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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