{"id":"b55615a6-4134-5528-afa1-abc5cd4e07e6","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-synapse-nitrotyrosine","predicate":"reduces_and_increases","statement":"Chronic soursop juice reduced synaptophysin immunoreactivity and increased 3-nitrotyrosine reactivity across the tested mouse genotypes.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a9a3cc88-2546-5d1d-866b-fb59b073d5c8","mechanism_event_label":"Chronic soursop juice reduced synaptophysin immunoreactivity and increased 3-nitrotyrosine reactivity across the tested mouse genotypes.","subject":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"object":{"id":"8a22895c-34f5-5301-88a8-8417a1fadf4a","slug":"mouse-synaptophysin-and-nitrotyrosine-profile","display_name":"Mouse brain synaptophysin and nitrotyrosine profile","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a9a3cc88-2546-5d1d-866b-fb59b073d5c8","stable_key":"cea4b417-bb71-5d5d-8fe1-4e175aca750c:graviola-juice-synapse-nitrotyrosine-event","event_type":"observed_relationship","label":"Chronic soursop juice reduced synaptophysin immunoreactivity and increased 3-nitrotyrosine reactivity across the tested mouse genotypes.","description":"Chronic soursop juice reduced synaptophysin immunoreactivity and increased 3-nitrotyrosine reactivity across the tested mouse genotypes.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a80086e7-d7cd-5487-b9ab-7ece7e008c12","slug":"commercial-soursop-juice-2016","display_name":"Commercial soursop juice used in the 2016 chronic mouse study","entity_type_key":"botanical"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8a22895c-34f5-5301-88a8-8417a1fadf4a","slug":"mouse-synaptophysin-and-nitrotyrosine-profile","display_name":"Mouse brain synaptophysin and nitrotyrosine profile","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Commercial soursop juice","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"12 months","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. 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(2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Brain synaptic and nitrative-stress markers","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a0bfe6db-dc46-5ce7-842e-71309b19150a","evidence_kind":"source_excerpt","locator":"Lines 33-42","start_line":33,"end_line":42,"excerpt":"## graviola-juice-synapse-nitrotyrosine\nChronic soursop juice reduced synaptophysin immunoreactivity and increased 3-nitrotyrosine reactivity across the tested mouse genotypes.\nModel/species: Three mouse tau genotypes\nTissue/system: Brain synaptic and nitrative-stress markers\nExposure: Commercial soursop juice\nRoute: Oral\nDuration: 12 months\nLimits: Marker changes are not a direct measure of human neurodegeneration and cannot identify which juice constituent caused them.\nPrimary reference: Chronic consumption of Annona muricata juice triggers and aggravates cerebral tau phosphorylation in wild-type and MAPT transgenic mice. (2016). https://pubmed.ncbi.nlm.nih.gov/27569447/ DOI: 10.1111/jnc.13835\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Three mouse tau genotypes","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dde73deb-4328-5cc7-aa41-04b7d845f4fa","stable_key":"import-cea4b417-bb71-5d5d-8fe1-4e175aca750c","title":"Graviola (Annona muricata): mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. 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