{"id":"b540bd62-dbd2-557b-a0b4-fb1ab06f535e","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-nsk-sd-lowers-blood-pressure","predicate":"reduces","statement":"Net changes of -5.55 mmHg systolic and -2.84 mmHg diastolic against placebo were reported after eight weeks at 2,000 FU per day.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"378fc188-f92b-51b2-bab9-c46dd271a24a","mechanism_event_label":"Net changes of -5.55 mmHg systolic and -2.84 mmHg diastolic against placebo were reported after eight weeks at 2,000 FU per day.","subject":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"object":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"378fc188-f92b-51b2-bab9-c46dd271a24a","stable_key":"33bef151-bdc7-5892-aff6-0345ab149739:eight-weeks-of-nsk-sd-lowers-blood-pressure-event","event_type":"observed_intervention","label":"Net changes of -5.55 mmHg systolic and -2.84 mmHg diastolic against placebo were reported after eight weeks at 2,000 FU per day.","description":"Arterial blood pressure","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9910223c-2a27-5d75-8003-91d72e71be9a","slug":"nsk-sd","display_name":"NSK-SD fermented soybean extract","entity_type_key":"chemical_species"},"role":"acting component","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9eda1162-1823-5c43-8e7d-4f2e4858c353","slug":"blood-pressure","display_name":"Arterial blood pressure","entity_type_key":"cellular_process"},"role":"component the finding is about","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"8 weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human (86 randomized, 73 completed, untreated systolic 130-159 mmHg, ages 20-80)","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Nattokinase, 2,000 FU per capsule","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Randomized, double-blind and placebo-controlled, but small and short, with industry affiliations. The confidence intervals reach close to zero (-10.5 to -0.57 and -5.33 to -0.33). 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Every reference in that document was resolved against live PubMed with its abstract read and its DOI cross-checked on 2026-09-23, and the EFSA novel-food opinion was retrieved and read in full. That check corrected two PMIDs that pointed at unrelated papers, two DOIs, and two papers recorded as carrying no erratum that do carry one; it also reversed three findings the supplied document had stated backwards. Two papers carry a published correction, recorded as such and not as a retraction. Three sources are not indexed in PubMed and are cited by what they have. Laboratory lineages are recorded, so the four papers from one group, the three from another and the two readings of a single applicant dossier cannot be counted as separate lines of support. Study-specific doses, units, populations and limitations retained; activity units are never converted between systems. 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The three-year randomized trial at the same 2,000 FU dose found no effect on blood pressure at all. The populations differ: the short trials enrolled people with elevated blood pressure and the long trial enrolled low-risk adults not selected for it, so regression to the mean and a floor effect are both available explanations alongside a real difference in duration or population.","resolution":"Unresolved. 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