{"id":"b52da52f-f41a-5166-9894-16527b8ff025","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-metabolic-positive","predicate":"changes","statement":"In 11 obese men, 150 mg/day resveratrol for 30 days increased muscle AMPK activation and SIRT1/PGC-1alpha protein, improved fatty-acid-supported mitochondrial respiration and reduced liver fat and selected metabolic markers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"062d90f5-6dd7-5af6-846a-291f12d555e3","mechanism_event_label":"A small controlled human study found several metabolic changes.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"9ef2ba8a-6626-5a73-a6e7-2a1bfc5ab64c","slug":"human-obese-resveratrol-metabolic-response","display_name":"Metabolic response to resveratrol in obese men","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"062d90f5-6dd7-5af6-846a-291f12d555e3","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-metabolic-positive-event","event_type":"observed_relationship","label":"A small controlled human study found several metabolic changes.","description":"In 11 obese men, 150 mg/day resveratrol for 30 days increased muscle AMPK activation and SIRT1/PGC-1alpha protein, improved fatty-acid-supported mitochondrial respiration and reduced liver fat and selected metabolic markers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9ef2ba8a-6626-5a73-a6e7-2a1bfc5ab64c","slug":"human-obese-resveratrol-metabolic-response","display_name":"Metabolic response to resveratrol in obese men","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b8e1bfa9-c412-5f35-97af-cfc722123d27","slug":"sirt1","display_name":"SIRT1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"95bc303f-ad04-59ea-8e1e-32f9e8b72c56","slug":"human-ampk-complexes","display_name":"Human AMP-activated protein kinase complexes","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind crossover; resVida preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"HOMA is not a clamp; no increase in mitochondrial content and no long-term disease outcome were demonstrated.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small controlled human study found several metabolic changes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22055504/ · DOI 10.1016/j.cmet.2011.10.002","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6c90763a-ef3e-5e22-807f-77a3bffeb3c2","evidence_kind":"source_excerpt","locator":"Lines 454-460","start_line":454,"end_line":460,"excerpt":"## resveratrol-human-metabolic-positive\nA small controlled human study found several metabolic changes.\nIn 11 obese men, 150 mg/day resveratrol for 30 days increased muscle AMPK activation and SIRT1/PGC-1alpha protein, improved fatty-acid-supported mitochondrial respiration and reduced liver fat and selected metabolic markers.\nModel: Randomized double-blind crossover; resVida preparation.\nLimitations: HOMA is not a clamp; no increase in mitochondrial content and no long-term disease outcome were demonstrated.\nEvidence access: Primary abstract\nCalorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. · 2011 · https://pubmed.ncbi.nlm.nih.gov/22055504/ · DOI 10.1016/j.cmet.2011.10.002","model_system":"Randomized double-blind crossover; resVida preparation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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