{"id":"b51b8bf4-ba2d-54b5-aa45-481416c878ef","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-low-glucose","predicate":"does_not_stimulate_under_low_glucose","statement":"Stevioside did not elicit islet calcium signals at 3 mM glucose in the tested mouse preparation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"6d01538c-9bf6-5d5f-b114-400783137cc9","mechanism_event_label":"The metabolic trigger still matters when a potentiator is present.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"82221442-71c1-538d-ae26-a3fcbe9254a1","slug":"mouse-low-glucose-islet-calcium","display_name":"Mouse low-glucose islet calcium response","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6d01538c-9bf6-5d5f-b114-400783137cc9","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-low-glucose-event","event_type":"observed_relationship","label":"The metabolic trigger still matters when a potentiator is present.","description":"Stevioside did not elicit islet calcium signals at 3 mM glucose in the tested mouse preparation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"82221442-71c1-538d-ae26-a3fcbe9254a1","slug":"mouse-low-glucose-islet-calcium","display_name":"Mouse low-glucose islet calcium response","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"32fb303f-db5a-51a8-8260-438b8168d0ad","slug":"mouse-trpm5","display_name":"Mouse calcium-activated monovalent cation channel / Trpm5","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text; supplementary Figure 3 description","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse islet calcium imaging at low versus stimulatory glucose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"This does not establish zero human hypoglycemia risk under all combinations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The metabolic trigger still matters when a potentiator is present.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28361903/ · DOI 10.1038/ncomms14733","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3d3304e1-80d0-5655-a243-3da5adb27ebf","evidence_kind":"source_excerpt","locator":"Lines 218-224","start_line":218,"end_line":224,"excerpt":"## stevia-low-glucose\nThe metabolic trigger still matters when a potentiator is present.\nStevioside did not elicit islet calcium signals at 3 mM glucose in the tested mouse preparation.\nModel: Mouse islet calcium imaging at low versus stimulatory glucose.\nLimitations: This does not establish zero human hypoglycemia risk under all combinations.\nEvidence access: Primary full text; supplementary Figure 3 description\nSteviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28361903/ · DOI 10.1038/ncomms14733","model_system":"Mouse islet calcium imaging at low versus stimulatory glucose.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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