{"id":"b510ba9c-0c90-59d2-8527-efa1e9ad1429","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-baat-glycine","predicate":"conjugates_to","statement":"The same expressed human BAAT also catalyzed glycine conjugation of cholic acid.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b098944d-9652-5fed-80e9-fe2fdf08684e","mechanism_event_label":"Glycine and taurine converge on the same bile-conjugating enzyme.","subject":{"id":"b1127d16-82be-5dd0-90db-aa1af23011f0","slug":"baat","display_name":"Human bile acid-CoA:amino acid N-acyltransferase / BAAT","entity_type_key":"protein"},"object":{"id":"be9d8bde-6521-5b10-8517-5bd8d7826b12","slug":"glycocholate","display_name":"Glycocholate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"b098944d-9652-5fed-80e9-fe2fdf08684e","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-baat-glycine-event","event_type":"observed_relationship","label":"Glycine and taurine converge on the same bile-conjugating enzyme.","description":"The same expressed human BAAT also catalyzed glycine conjugation of cholic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b1127d16-82be-5dd0-90db-aa1af23011f0","slug":"baat","display_name":"Human bile acid-CoA:amino acid N-acyltransferase / BAAT","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"be9d8bde-6521-5b10-8517-5bd8d7826b12","slug":"glycocholate","display_name":"Glycocholate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8d02cbb8-2d1f-5dc6-95ad-20c1e3d33724","slug":"choloyl-coa","display_name":"Choloyl-CoA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Recombinant human enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Shared enzyme use does not establish clinical competition or a need to balance glycine and taurine supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Glycine and taurine converge on the same bile-conjugating enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Glycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8034703/","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8144e17f-2926-5606-b65f-d3b16ce6367a","evidence_kind":"source_excerpt","locator":"Lines 305-311","start_line":305,"end_line":311,"excerpt":"## taurine-baat-glycine\nGlycine and taurine converge on the same bile-conjugating enzyme.\nThe same expressed human BAAT also catalyzed glycine conjugation of cholic acid.\nModel: Recombinant human enzyme.\nLimitations: Shared enzyme use does not establish clinical competition or a need to balance glycine and taurine supplements.\nEvidence access: Primary abstract\nGlycine and taurine conjugation of bile acids by a single enzyme. Molecular cloning and expression of human liver bile acid CoA:amino acid N-acyltransferase. · 1994 · https://pubmed.ncbi.nlm.nih.gov/8034703/","model_system":"Recombinant human enzyme.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"c6cb77619a374d9b1b04830032fdd3b33d269d160df5baba3778fad5adf57db5","revision_id":"cc45c491-cc6a-5426-ab72-d7c6d26c3614","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}