{"id":"b4dd8fbe-fbdd-51a8-8716-8768733844e0","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-acth-not-adrenal-diagnosis","predicate":"deprivation-alters","statement":"The 1958 depletion study found an impaired eosinopenic response to ACTH, while urinary 17-ketosteroid excretion remained normal; the authors did not interpret this pattern as sufficient evidence of adrenal cortical hypofunction.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a72f26c6-409d-5678-a4e9-60bb7e20a973","mechanism_event_label":"The altered hormone-response test did not establish adrenal failure.","subject":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"object":{"id":"c814d064-dbf7-5773-a9c5-87c374a0f939","slug":"acth-eosinopenic-response","display_name":"Eosinopenic response to ACTH","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a72f26c6-409d-5678-a4e9-60bb7e20a973","stable_key":"f992b796-377d-53bf-a39b-7e5d41dbe194:b5-clin-acth-not-adrenal-diagnosis-event","event_type":"observed_intervention","label":"The altered hormone-response test did not establish adrenal failure.","description":"The 1958 depletion study found an impaired eosinopenic response to ACTH, while urinary 17-ketosteroid excretion remained normal; the authors did not interpret this pattern as sufficient evidence of adrenal cortical hypofunction.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ca23a70f-b332-57f4-8f4f-a373815f94e7","slug":"urinary-17-ketosteroid-excretion","display_name":"Urinary 17-ketosteroid excretion","entity_type_key":"cellular_process"},"role":"preserved measured endpoint","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e3aec528-bdfb-54a8-9b32-53fd3f1b9ff9","slug":"omega-methyl-pantothenate","display_name":"Omega-methyl pantothenic acid","entity_type_key":"small_molecule"},"role":"additional exposure in the antagonist pair","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"7bc62072-9517-5563-a3b8-8c5ab64a464b","slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c814d064-dbf7-5773-a9c5-87c374a0f939","slug":"acth-eosinopenic-response","display_name":"Eosinopenic response to ACTH","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary PDF pp.1643–1654; design, results and discussion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold. This historical indirect test is not a modern diagnostic assay for adrenal insufficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pantothenate","display_name":"Pantothenate (vitamin B5)","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The altered hormone-response test did not establish adrenal failure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Whole-person symptoms, serum and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7a724264-1756-544a-845e-276f6af1dd3a","evidence_kind":"source_excerpt","locator":"Lines 1173-1185","start_line":1173,"end_line":1185,"excerpt":"### b5-clin-acth-not-adrenal-diagnosis\nThe 1958 depletion study found an impaired eosinopenic response to ACTH, while urinary 17-ketosteroid excretion remained normal; the authors did not interpret this pattern as sufficient evidence of adrenal cortical hypofunction.\nCondition category: nutrient_deficiency\nnutrient_topic: Pantothenic acid (vitamin B5) research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The altered hormone-response test did not establish adrenal failure.\norganism: Homo sapiens\ntissue_or_cell_type: Whole-person symptoms, serum and urine\nexperimental_model: Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls\nlimitations: Very small historical cohort; other vitamins and formula composition were controlled imperfectly. Diet-only and antagonist groups are distinguished. Measurements do not establish a universal symptom, adrenal disease mechanism or cellular CoA threshold. This historical indirect test is not a modern diagnostic assay for adrenal insufficiency.\nexposure: Tube-fed experimental formula; controls received pantothenic acid 20 mg/day, antagonist pair 750 then 1000 mg/day omega-methyl compound; recovery included 4000 mg/day vitamin. One man per pair received 10.8 mEq/day extra potassium.\ncross_nutrient: false\nevidence_location: Primary PDF pp.1643–1654; design, results and discussion.\n[b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","model_system":"Historical controlled feeding study in six adult male volunteers; two diet-only deficient, two deficient plus antagonist, two supplemented controls","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b5-clin-hodges1958] Pantothenic acid deficiency in man. (1958). https://pubmed.ncbi.nlm.nih.gov/13587673/ DOI: 10.1172/jci103756","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0716b500-dd0b-5425-b9d0-d88bc9c09e86","stable_key":"import-f992b796-377d-53bf-a39b-7e5d41dbe194","title":"Pantothenic acid (vitamin B5): coenzyme A, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b5a49f5a2373ca6064c9a4e014e052dad2f6f199a82bb09b26b82b831c36110b","revision_id":"78f3e793-f084-5ee2-8703-b661c4b650bf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}