{"id":"b4cf72ae-78ae-5e22-b60b-651acd0c04aa","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-mouse-diabetes-null","predicate":"knockout_did_not_increase","statement":"Adding Carns1 deficiency to Lepr-db/db mice did not further increase the already elevated renal malondialdehyde adducts.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4d5db385-bf9b-5ec8-b3a5-6d996603c9ac","mechanism_event_label":"The tested diabetic injury marker did not worsen further.","subject":{"id":"17665d7f-0637-5c4c-bb6d-611795507168","slug":"mouse-carns1","display_name":"Mouse carnosine synthase / Carns1","entity_type_key":"protein"},"object":{"id":"3af8e553-25b8-5c71-90e9-8315823f43fa","slug":"mouse-diabetic-renal-mda-adducts","display_name":"Mouse diabetic-kidney malondialdehyde adducts","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4d5db385-bf9b-5ec8-b3a5-6d996603c9ac","stable_key":"ae1ed35d-8ce7-5936-9067-a641374bbf79:carnosine-mouse-diabetes-null-event","event_type":"observed_relationship","label":"The tested diabetic injury marker did not worsen further.","description":"Adding Carns1 deficiency to Lepr-db/db mice did not further increase the already elevated renal malondialdehyde adducts.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"17665d7f-0637-5c4c-bb6d-611795507168","slug":"mouse-carns1","display_name":"Mouse carnosine synthase / Carns1","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3af8e553-25b8-5c71-90e9-8315823f43fa","slug":"mouse-diabetic-renal-mda-adducts","display_name":"Mouse diabetic-kidney malondialdehyde adducts","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9998eb9b-0d09-58c9-885b-a442477dec8d","slug":"carnosine","display_name":"L-Carnosine / beta-alanyl-L-histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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