{"id":"b4b4f337-3a80-5630-a65e-d28496d67602","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-repletion-tubular-recovery","predicate":"repletion_precedes_recovery_of","statement":"Thiamine administration was followed by rapid resolution of tubular dysfunction, acidosis and electrolyte imbalance in the two cases.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e7637b28-f094-52a8-b617-7cd0f6c6599d","mechanism_event_label":"Replacing B1 was followed by recovery of the kidney-handling abnormality.","subject":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"object":{"id":"3af495a2-51d2-59ff-be54-a11c13d40acb","slug":"proximal-renal-tubular-function","display_name":"Proximal renal tubular function","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e7637b28-f094-52a8-b617-7cd0f6c6599d","stable_key":"46d15d9e-d3b5-544d-ba01-b785aa3e4f42:b1-repletion-tubular-recovery-event","event_type":"observed_intervention","label":"Replacing B1 was followed by recovery of the kidney-handling abnormality.","description":"Thiamine administration was followed by rapid resolution of tubular dysfunction, acidosis and electrolyte imbalance in the two cases.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7867f624-5e41-545f-9a2b-9d1b4f58ce78","slug":"renal-tubular-electrolyte-loss","display_name":"Renal tubular electrolyte loss","entity_type_key":"cellular_process"},"role":"parallel_resolution","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c6d5b185-5aa5-5626-9ab8-9925bfe4c27b","slug":"thiamine-deficiency-lactic-acidosis","display_name":"Lactic acidosis in thiamine deficiency","entity_type_key":"cellular_process"},"role":"parallel_resolution","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"36b7c3eb-068b-500f-af1c-078829df1ecc","slug":"thiamine","display_name":"Thiamine (vitamin B1)","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"3af495a2-51d2-59ff-be54-a11c13d40acb","slug":"proximal-renal-tubular-function","display_name":"Proximal renal tubular function","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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Study references: [b1-maiorana2014] Acute thiamine deficiency and refeeding syndrome: Similar findings but different pathogenesis (2014). https://pubmed.ncbi.nlm.nih.gov/24985016/ DOI: 10.1016/j.nut.2014.02.019","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"158d2c03-ac8c-589f-8270-c468165ae346","stable_key":"import-46d15d9e-d3b5-544d-ba01-b785aa3e4f42","title":"Thiamine: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"f376512fb3310141315548015b387833e3af45146e73fb73cd02cee20e4ddb9c","revision_id":"53bc5eda-dec8-58cc-a56f-a9eb4ab036ef","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}