{"id":"b4b03604-fc60-5c3b-856e-c5453887368c","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-10-human-glucuronides","predicate":"produces_detectable_exposure","statement":"After oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"37375cae-000b-5014-a004-6aabfd974130","mechanism_event_label":"After oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.","subject":{"id":"3ed63f7e-8320-5dc1-90f6-c3cc9f81591f","slug":"ginger-2008-pk-preparation","display_name":"Ginger preparation in the 2008 human pharmacokinetic study","entity_type_key":"small_molecule"},"object":{"id":"c338b16e-b326-51ce-86a8-847e32fed235","slug":"10-gingerol-plasma-glucuronide-pool","display_name":"10-Gingerol plasma glucuronides, attachment position unresolved","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"37375cae-000b-5014-a004-6aabfd974130","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-10-human-glucuronides-event","event_type":"observed_relationship","label":"After oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.","description":"After oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"3ed63f7e-8320-5dc1-90f6-c3cc9f81591f","slug":"ginger-2008-pk-preparation","display_name":"Ginger preparation in the 2008 human pharmacokinetic study","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c338b16e-b326-51ce-86a8-847e32fed235","slug":"10-gingerol-plasma-glucuronide-pool","display_name":"10-Gingerol plasma glucuronides, attachment position unresolved","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bf4fa054-0b02-5fc2-82dd-2e53b36033b3","slug":"10-gingerol","display_name":"10-Gingerol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Single ginger-product dose 100 mg to 2 g","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Blood sampling 15 min to 72 h","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"27 healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Conjugates assessed after hydrolysis; measured total/conjugated exposure is not free parent concentration or tissue target engagement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"27 healthy human volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18708382/ DOI: 10.1158/1055-9965.EPI-07-2934","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral mixed ginger product","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Plasma","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"52a8dda9-5505-5b5d-a26d-63f8dd6f0fe4","evidence_kind":"source_excerpt","locator":"Lines 371-380","start_line":371,"end_line":380,"excerpt":"## gingerols-10-human-glucuronides\nAfter oral ginger, plasma 10-gingerol glucuronides were detected through enzymatic hydrolysis; unconjugated 10-gingerol was not detected in this study.\nModel/species: 27 healthy human volunteers\nTissue: Plasma\nExposure: Single ginger-product dose 100 mg to 2 g\nRoute: Oral mixed ginger product\nDuration: Blood sampling 15 min to 72 h\nLimits: Conjugates assessed after hydrolysis; measured total/conjugated exposure is not free parent concentration or tissue target engagement.\nPrimary reference: Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. (2008). https://pubmed.ncbi.nlm.nih.gov/18708382/ DOI: 10.1158/1055-9965.EPI-07-2934\nAccess: Primary PubMed abstract.","model_system":"27 healthy human volunteers","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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