{"id":"b4603d11-59e9-58d8-95f7-b2a9f4d392c2","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-caffeic-disappearance","predicate":"showed","statement":"Caffeic-acid disappearance was 95 +/- 4% in the same crossover design.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"50fab299-6f5d-59ba-b5ec-6525e5b82ec7","mechanism_event_label":"The free acid behaved differently from its quinic-acid ester.","subject":{"id":"049cdeae-4cd8-5eac-b3c5-5a24a235a945","slug":"caffeic-acid","display_name":"Caffeic acid","entity_type_key":"small_molecule"},"object":{"id":"6c04b584-2e8e-5044-b070-46a714aa7030","slug":"caffeic-small-intestinal-disappearance","display_name":"Caffeic acid disappearance before ileostomy collection","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"50fab299-6f5d-59ba-b5ec-6525e5b82ec7","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-caffeic-disappearance-event","event_type":"observed_intervention","label":"The free acid behaved differently from its quinic-acid ester.","description":"Caffeic-acid disappearance was 95 +/- 4% in the same crossover design.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"049cdeae-4cd8-5eac-b3c5-5a24a235a945","slug":"caffeic-acid","display_name":"Caffeic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6c04b584-2e8e-5044-b070-46a714aa7030","slug":"caffeic-small-intestinal-disappearance","display_name":"Caffeic acid disappearance before ileostomy collection","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/11208940.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8\", \"start_char\": 0, \"end_char\": 1299, \"text_sha256\": \"651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order crossover in seven ileostomy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"2.8 mmol chlorogenic acid or caffeic acid on separate days; 24-hour collections","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Disappearance from ileal effluent is not intact-parent systemic bioavailability. Participants lacked normal colonic processing; no therapeutic outcome was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The free acid behaved differently from its quinic-acid ester.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p11208940] Chlorogenic acid and caffeic acid are absorbed in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11208940/ DOI: 10.1093/jn/131.1.66","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Small intestine; ileal effluent and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a9dcebbd-f82f-5193-878f-01c61f4b81ce","evidence_kind":"source_excerpt","locator":"Lines 152-163","start_line":152,"end_line":163,"excerpt":"### chlorogenic_acid-caffeic-disappearance\nCaffeic-acid disappearance was 95 +/- 4% in the same crossover design.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The free acid behaved differently from its quinic-acid ester.\norganism: Human\ntissue_or_cell_type: Small intestine; ileal effluent and urine\nexperimental_model: Randomized-order crossover in seven ileostomy volunteers\nlimitations: Disappearance from ileal effluent is not intact-parent systemic bioavailability. Participants lacked normal colonic processing; no therapeutic outcome was tested.\nexposure: 2.8 mmol chlorogenic acid or caffeic acid on separate days; 24-hour collections\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/11208940.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8\", \"start_char\": 0, \"end_char\": 1299, \"text_sha256\": \"651ac6849ea1490afeee5c905352bda75c8701decbcdf68f1d22dec05af06fd8\"}\n[chlorogenic_acid-p11208940] Chlorogenic acid and caffeic acid are absorbed in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11208940/ DOI: 10.1093/jn/131.1.66","model_system":"Randomized-order crossover in seven ileostomy volunteers","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p11208940] Chlorogenic acid and caffeic acid are absorbed in humans. (2001). https://pubmed.ncbi.nlm.nih.gov/11208940/ DOI: 10.1093/jn/131.1.66","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dabd56b55fb10d82913b222343d9592d3baf61ef3cc81cf47f3e3e7537eb7992","revision_id":"340aee2f-52a6-56aa-99c1-0a24c534752a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}