{"id":"b4310a42-133c-56c8-a5db-181a61e3f740","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-citrate-oxide-solubility","predicate":"has_greater_measured_solubility_than","statement":"Magnesium citrate dissolved more readily than oxide in the tested gastric-acid simulation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9469eb3b-db74-5713-9e40-c84e6dc2331b","mechanism_event_label":"Chemical form can change dissolution before absorption.","subject":{"id":"b248ac1c-e9c4-560e-b8a0-5e2757b03bcc","slug":"magnesium-citrate","display_name":"Magnesium citrate","entity_type_key":"chemical_species"},"object":{"id":"f3c2d75b-ad3c-554e-adbb-89ebea103e2b","slug":"magnesium-oxide","display_name":"Magnesium oxide","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"9469eb3b-db74-5713-9e40-c84e6dc2331b","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:mg-citrate-oxide-solubility-event","event_type":"biochemical_relationship","label":"Chemical form can change dissolution before absorption.","description":"Magnesium citrate dissolved more readily than oxide in the tested gastric-acid simulation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"released_ion","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b248ac1c-e9c4-560e-b8a0-5e2757b03bcc","slug":"magnesium-citrate","display_name":"Magnesium citrate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"f3c2d75b-ad3c-554e-adbb-89ebea103e2b","slug":"magnesium-oxide","display_name":"Magnesium oxide","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Formulation/acid environment -> magnesium availability.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"In-vitro water/acid comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Specific preparations and assay conditions, not an exhaustive ranking of commercial supplements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Cell-free chemical preparation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Chemical form can change dissolution before absorption.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mg-lindberg1990] Magnesium bioavailability from magnesium citrate and magnesium oxide (1990). https://pubmed.ncbi.nlm.nih.gov/2407766/ DOI: 10.1080/07315724.1990.10720349","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Simulated gastric solutions or human urinary Mg response, as specified in model","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"df0622b0-8449-5419-9996-96ca9207b411","evidence_kind":"source_excerpt","locator":"Lines 1628-1638","start_line":1628,"end_line":1638,"excerpt":"### mg-citrate-oxide-solubility\nMagnesium citrate dissolved more readily than oxide in the tested gastric-acid simulation.\nCondition category: normal\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Chemical form can change dissolution before absorption.\norganism: Cell-free chemical preparation\ntissue_or_cell_type: Simulated gastric solutions or human urinary Mg response, as specified in model\nexperimental_model: In-vitro water/acid comparison.\nlimitations: Specific preparations and assay conditions, not an exhaustive ranking of commercial supplements.\ncross_nutrient: Formulation/acid environment -> magnesium availability.\n[mg-lindberg1990] Magnesium bioavailability from magnesium citrate and magnesium oxide (1990). https://pubmed.ncbi.nlm.nih.gov/2407766/ DOI: 10.1080/07315724.1990.10720349","model_system":"In-vitro water/acid comparison.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. 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