{"id":"b42743c7-5b40-50eb-ac63-bee92b575d24","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-glycogen-null","predicate":"does_not_change","statement":"Vanadyl did not change basal or insulin-stimulated muscle glycogen-synthase activity in the six-week study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"82d9519b-7305-5f36-9cdd-5e045a3f0f6e","mechanism_event_label":"A change in upstream signaling did not establish a change at every downstream enzyme.","subject":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"object":{"id":"7211d360-f091-52cb-b88d-a01f982a6c92","slug":"human-vanadyl-glycogen-synthase","display_name":"Muscle glycogen-synthase activity after vanadyl sulfate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"82d9519b-7305-5f36-9cdd-5e045a3f0f6e","stable_key":"335be270-ea4a-5c8e-ad04-964fd22a439e:vanadium-human-glycogen-null-event","event_type":"observed_relationship","label":"A change in upstream signaling did not establish a change at every downstream enzyme.","description":"Vanadyl did not change basal or insulin-stimulated muscle glycogen-synthase activity in the six-week study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"68c1e8ab-2afe-5c6e-bae1-45b9bb505795","slug":"vanadyl-sulfate","display_name":"Vanadyl sulfate","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7211d360-f091-52cb-b88d-a01f982a6c92","slug":"human-vanadyl-glycogen-synthase","display_name":"Muscle glycogen-synthase activity after vanadyl sulfate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c5cbad45-22c6-594b-ab6b-71880dab1b24","slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human muscle assay from the dose-ranging trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Assay result is not a full glycogen-flux measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vanadium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vanadium","display_name":"Vanadium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A change in upstream signaling did not establish a change at every downstream enzyme.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f98f8b37-439e-5997-9265-79cc88d8a05c","evidence_kind":"source_excerpt","locator":"Lines 398-404","start_line":398,"end_line":404,"excerpt":"## vanadium-human-glycogen-null\nA change in upstream signaling did not establish a change at every downstream enzyme.\nVanadyl did not change basal or insulin-stimulated muscle glycogen-synthase activity in the six-week study.\nModel: Human muscle assay from the dose-ranging trial.\nLimitations: Assay result is not a full glycogen-flux measurement.\nEvidence access: Primary abstract\nMetabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10726921/ · DOI 10.1016/s0026-0495(00)90418-9","model_system":"Human muscle assay from the dose-ranging trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e4d5d0ba-529b-540f-96ed-e719d116ccfd","stable_key":"import-335be270-ea4a-5c8e-ad04-964fd22a439e","title":"Vanadium: speciation, phosphate-sensitive enzymes and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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