{"id":"b3d95aae-6992-5784-a167-24ff1f04a562","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-aging-cd38","predicate":"associated_with_increase","statement":"Aged mouse liver and white adipose tissue accumulated CD38-positive immune cells, including macrophages/monocytes, with increased expression per cell in several comparisons.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"cc5e7f60-9255-512c-8785-d96778c4e9b8","mechanism_event_label":"More NAD-consuming immune cells can change a tissue metabolite pool.","subject":{"id":"cc7156f1-90d0-5ca9-9782-d52a1c1a3246","slug":"mouse-aging-inflammatory-cell-accumulation","display_name":"Inflammatory-cell accumulation during mouse aging","entity_type_key":"cellular_process"},"object":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"cc5e7f60-9255-512c-8785-d96778c4e9b8","stable_key":"8c946991-97f0-55ee-8df0-00e67621962f:nad-plus-aging-cd38-event","event_type":"observed_relationship","label":"More NAD-consuming immune cells can change a tissue metabolite pool.","description":"Aged mouse liver and white adipose tissue accumulated CD38-positive immune cells, including macrophages/monocytes, with increased expression per cell in several comparisons.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"cc7156f1-90d0-5ca9-9782-d52a1c1a3246","slug":"mouse-aging-inflammatory-cell-accumulation","display_name":"Inflammatory-cell accumulation during mouse aging","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"77c40786-fc17-5efb-887f-52a76163a9ba","slug":"mouse-cd38","display_name":"Mouse CD38","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"283ed24b-06a1-50aa-9281-df3bac6ce37e","slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Young versus aged mice; flow cytometry, histology and macrophage experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell abundance and expression observations do not alone quantify absolute tissue NAD flux.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"NAD+ collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nad-plus","display_name":"NAD+","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"More NAD-consuming immune cells can change a tissue metabolite pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33199925/ · DOI 10.1038/s42255-020-00298-z","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"81789cec-6f0b-5d96-bafc-0b748ad5c9f3","evidence_kind":"source_excerpt","locator":"Lines 100-106","start_line":100,"end_line":106,"excerpt":"## nad-plus-aging-cd38\nMore NAD-consuming immune cells can change a tissue metabolite pool.\nAged mouse liver and white adipose tissue accumulated CD38-positive immune cells, including macrophages/monocytes, with increased expression per cell in several comparisons.\nModel: Young versus aged mice; flow cytometry, histology and macrophage experiments.\nLimitations: Cell abundance and expression observations do not alone quantify absolute tissue NAD flux.\nEvidence access: Primary full text\nCD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels. · 2020 · https://pubmed.ncbi.nlm.nih.gov/33199925/ · DOI 10.1038/s42255-020-00298-z","model_system":"Young versus aged mice; flow cytometry, histology and macrophage experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"f59aa302-d463-5462-876f-e21e64861eac","stable_key":"import-8c946991-97f0-55ee-8df0-00e67621962f","title":"NAD+: compartmental supply, consumption and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"9f5324d0d652c80ad630b3100e28ce34cd2ce260ea2e1324332a4262ce72ae09","revision_id":"0e07909c-e8bc-5950-bafc-61371d9d6412","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}