{"id":"b3825c10-3817-529e-b26b-3cd250461786","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-tpn-sulfur","predicate":"reported_deficiency_associated_with","statement":"The prolonged-TPN case developed amino-acid intolerance with high plasma methionine, high urinary sulfite/thiosulfate and low urinary sulfate.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a09d3975-7afa-5e35-9557-31ff929f5772","mechanism_event_label":"The sulfur-handling pathway stalled when molybdenum supply was inadequate.","subject":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"object":{"id":"d7c8a43b-3ce2-59bb-8e28-14a5b29231a4","slug":"tpn-amino-acid-intolerance","display_name":"Amino-acid intolerance during parenteral nutrition","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a09d3975-7afa-5e35-9557-31ff929f5772","stable_key":"dc8975b1-95ff-5d9b-be17-a1c04610cca7:mo-tpn-sulfur-event","event_type":"observed_intervention","label":"The sulfur-handling pathway stalled when molybdenum supply was inadequate.","description":"The prolonged-TPN case developed amino-acid intolerance with high plasma methionine, high urinary sulfite/thiosulfate and low urinary sulfate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9d39f561-740b-5f67-bba7-8a72ef612a99","slug":"methionine","display_name":"L-Methionine","entity_type_key":"small_molecule"},"role":"upstream amino acid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"914ace7c-9176-53f7-80a9-9ee71d26ea52","slug":"sulfite","display_name":"Sulfite / SO3(2-)","entity_type_key":"ion"},"role":"accumulated metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"3634af03-823b-584f-8e8e-e6ab6e3fbb60","slug":"sulfate","display_name":"Sulfate / SO4(2-)","entity_type_key":"ion"},"role":"reduced product","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"bf313203-7930-5d8b-9c8c-a10559dafcaf","slug":"suox","display_name":"Human sulfite oxidase / SUOX","entity_type_key":"protein"},"role":"implicated enzyme","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"36447b98-3392-559f-b76c-035726a2538e","slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"d7c8a43b-3ce2-59bb-8e28-14a5b29231a4","slug":"tpn-amino-acid-intolerance","display_name":"Amino-acid intolerance during parenteral nutrition","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/molybdenum-research/6795919.publisher-abstract.txt\", \"locator\": \"Exact primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\", \"start_char\": 0, \"end_char\": 1820, \"text_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Single case during prolonged total parenteral nutrition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Prolonged parenteral nutrition followed by ammonium molybdate","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Rare single case. The paper reports 300 micrograms/day ammonium molybdate, not 300 micrograms elemental molybdenum. Historical observation, not a general regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Molybdenum research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"molybdenum","display_name":"Molybdenum","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The sulfur-handling pathway stalled when molybdenum supply was inadequate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mo-p6795919] Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. (1981). https://pubmed.ncbi.nlm.nih.gov/6795919/ DOI: 10.1093/ajcn/34.11.2551","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic symptoms; plasma and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"7fcd8bb9-0deb-5bd4-a7dc-59b31bb8c8ef","evidence_kind":"source_excerpt","locator":"Lines 1119-1130","start_line":1119,"end_line":1130,"excerpt":"### mo-tpn-sulfur\nThe prolonged-TPN case developed amino-acid intolerance with high plasma methionine, high urinary sulfite/thiosulfate and low urinary sulfate.\nCondition category: nutrient_deficiency\nnutrient_topic: Molybdenum research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The sulfur-handling pathway stalled when molybdenum supply was inadequate.\norganism: Homo sapiens\ntissue_or_cell_type: Systemic symptoms; plasma and urine\nexperimental_model: Single case during prolonged total parenteral nutrition\nlimitations: Rare single case. The paper reports 300 micrograms/day ammonium molybdate, not 300 micrograms elemental molybdenum. Historical observation, not a general regimen.\nexposure: Prolonged parenteral nutrition followed by ammonium molybdate\nevidence_span: {\"source_cache\": \"artifacts/molybdenum-research/6795919.publisher-abstract.txt\", \"locator\": \"Exact primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\", \"start_char\": 0, \"end_char\": 1820, \"text_sha256\": \"d2838a46a598539818059c1a1f8295e283334afced15326a6b5ba1a6104cbfd7\"}\n[mo-p6795919] Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. (1981). https://pubmed.ncbi.nlm.nih.gov/6795919/ DOI: 10.1093/ajcn/34.11.2551","model_system":"Single case during prolonged total parenteral nutrition","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mo-p6795919] Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. (1981). https://pubmed.ncbi.nlm.nih.gov/6795919/ DOI: 10.1093/ajcn/34.11.2551","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1aa6da60-8284-5252-8dd9-ac2250d5ced5","stable_key":"import-dc8975b1-95ff-5d9b-be17-a1c04610cca7","title":"Molybdenum: cofactor assembly, sulfur metabolism and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"143147eb9ac7fe750bdd33bb50d7773bc0cd49cc94faf219aebce3c3d760dd8f","revision_id":"90c2239d-290b-5e16-815a-f94d30569ebd","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}