{"id":"b3541d75-8c07-51cd-843d-2ee5e3bec3fb","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bdnf-induction","predicate":"increases","statement":"Lithium increased cellular BDNF in rat cortical neurons after three days.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3a9a5eb8-bddf-5b79-8601-e8ef7a68dad3","mechanism_event_label":"A survival-supporting signal rose over days.","subject":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"object":{"id":"8c87c2a6-f771-5d9e-b6ff-7b0f4923cd59","slug":"rat-bdnf","display_name":"Rat brain-derived neurotrophic factor / Bdnf","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"3a9a5eb8-bddf-5b79-8601-e8ef7a68dad3","stable_key":"b7798a90-72a3-5454-a321-c4be88bf0cc4:lithium-bdnf-induction-event","event_type":"observed_relationship","label":"A survival-supporting signal rose over days.","description":"Lithium increased cellular BDNF in rat cortical neurons after three days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"13b4b09c-4581-58f6-9792-9a78125963e8","slug":"lithium-ion","display_name":"Lithium ion (Li+)","entity_type_key":"ion"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8c87c2a6-f771-5d9e-b6ff-7b0f4923cd59","slug":"rat-bdnf","display_name":"Rat brain-derived neurotrophic factor / Bdnf","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e2e3902-5e26-52e3-9c85-1d7c0ace1637","slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat primary cortical neurons; companion excitotoxicity experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Time-dependent culture finding; not guaranteed human blood BDNF elevation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Lithium collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"lithium","display_name":"Lithium","entity_type_key":"nutrient_element"}},{"dimension":"plain_language","value_text":"A survival-supporting signal rose over days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12504924/ · DOI 10.1016/s0028-3908(02)00217-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4851b18b-8edc-59b9-a4eb-d699dce83965","evidence_kind":"source_excerpt","locator":"Lines 208-214","start_line":208,"end_line":214,"excerpt":"## lithium-bdnf-induction\nA survival-supporting signal rose over days.\nLithium increased cellular BDNF in rat cortical neurons after three days.\nModel: Rat primary cortical neurons; companion excitotoxicity experiments.\nLimitations: Time-dependent culture finding; not guaranteed human blood BDNF elevation.\nEvidence access: Primary abstract\nLithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12504924/ · DOI 10.1016/s0028-3908(02)00217-4","model_system":"Rat primary cortical neurons; companion excitotoxicity experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b2dd2f3c-5c4c-5a12-9a0d-91b521ffcf98","stable_key":"import-b7798a90-72a3-5454-a321-c4be88bf0cc4","title":"Lithium: metal-sensitive enzymes, transport and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"dc67e965ba78458cf2d88d000d687641d9104354115ab16529a3a64941bd777d","revision_id":"4af127bf-9ccc-516b-9481-fafd453c2c35","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}